Epigenetic Reprogramming Scientist

Ovelle; Boston, Northern (MA, KY); Hybrid; USD 120,000 - 190,000; Full time

Benefits offered by this job

12.5 paid holidays

PTO 3 weeks annually

Medical, Dental, Vision

Matching 401(k)

Up to 12 weeks paid parental leave

Tuition reimbursement for continuing教育

Job summary

Ovelle is a research-first startup advancing IVG by engineering epigenetic reprogramming in human iPSCs to produce eggs. You will lead genome-wide epigenetic profiling, build analytical toolkits, and develop strategies to master reprogramming beyond current protocols.

The role offers collaborative, cutting-edge research with a strong emphasis on reproducibility and publication. This position focuses on pushing the frontier of oogenesis, driving developmental competence of eggs, and contributing

Qualifications

• Deep knowledge of epigenetics and reprogramming in germ cells, embryos, or iPSCs.
• Hands-on human iPSC culture and related cell biology techniques.
• Proven genome engineering experience, including CRISPR knock-in/knockout.
• Experience with epigenetic profiling methods and multi-omics integration.
• Strong computational skills and ability to integrate bulk and single-cell data.
• PhD in stem cell biology, epigenetics, or related field, or equivalent work.

Responsibilities

• Lead genome-wide epigenetic reprogramming efforts during oogenesis.
• Develop and optimize tools to measure and benchmark epigenetic states.
• Engineer reprogramming strategies with inducible transcription factor circuits.
• Integrate epigenetic data with transcriptional programs to guide cell identity.
• Diagnose and address upstream molecular events causing abnormalities.
• Collaborate with teams and publish findings with the scientific community.

Skills

Epigenetics

iPSC culture

CRISPR engineering

Single-cell RNA-seq

Data analysis

Bioinformatics

Education

PhD in stem cell biology

Related field expertise

Tools

bisulfite sequencing

EM-seq

ChIP-seq

CUT&RUN

ATAC-seq

Hi-C

Job description

Ovelle is revolutionizing fertility treatment through human in vitro oogenesis—producing eggs from somatic cells. We have developed technology to create the cell types of the ovary from human induced pluripotent stem cells (iPSCs) by manipulating expression of transcription factors and RNA-binding proteins. Notably, we are the first company to produce meiotic oocyte-like cells from human iPSCs. This is an important step towards in vitro oogenesis because activating meiosis has been a key challenge in the field. We are incorporating these meiotic oocyte‑like cells into ovarian organoids to create synthetic ovaries capable of producing eggs. By innovating egg production, we aim to make fertility treatments more accessible and affordable. If we are successful, it will mark a paradigm shift in treatments for infertility, and offer a new path to parenthood for millions of people around the world. Come help us build the exciting future we all want to live in.

About the Specific Role:

We seek an Epigenetic Reprogramming Scientist to lead our effort to control the genome-wide epigenetic reprogramming that happens during oogenesis. You will build the biological and analytical toolkit for measuring, benchmarking, and controlling all aspects of epigenetics (including DNA methylation, histone modifications, chromatin accessibility, and 3D genome organization) to drive oogenesis in vitro and ensure consistently high developmental competence of the resulting eggs. This role offers a rare chance to own the hardest, most consequential step in the IVG problem, in a field with immense potential to impact global health and happiness.

How You Will Contribute:

• Engineer human iPSCs for massively pooled screens of epigenetic perturbations.
• Establish and optimize long‑term culture systems that drive cells into oogonia and beyond
• Measure epigenetic characteristics of in vitro organoid systems and in vivo counterparts, using cutting‑edge tools to analyze epigenetic marks at the single cell level.
• Computationally integrate data across different epigenetic modalities (DNA methylation, histone marks) and connect epigenetic state to transcriptional program and cell identity.
• Diagnose and correct the upstream molecular events that cause epigenetic abnormalities.
• Develop novel synthetic‑biology strategies, including inducible transcription‑factor and epigenetic‑modifier circuits, to control reprogramming beyond what current protocols achieve

Qualifications:

• Exceptional scientific talent, creativity, and rigor
• Deep knowledge of epigenetics, especially DNA methylation dynamics and reprogramming (in germ cells, the early embryo, or iPSC reprogramming)
• Human iPSC/stem cell culture experience
• Hands‑on synthetic biology and genome engineering: CRISPR knock‑in and knockout, reporter and inducible‑expression construct design, and pooled screens of genetic perturbations.
• Experience with epigenetic profiling methods (bisulfite/EM‑seq, ChIP‑seq/CUT&RUN, ATAC‑seq, Hi‑C)
• Strong computational skills for analysis of epigenetic data, and familiarity with bulk and single‑cell RNA‑seq analysis and its integration with epigenomic data
• PhD in stem cell biology, epigenetics, molecular or developmental biology, synthetic biology, or a related field; or proven innovative work in the field

Ovelle is a research‑first startup where scientists work together on only one deep and important problem: IVG. We operate like a fast, efficient academic lab without constraints. We’re committed to sharing our work with the scientific community and welcome collaborations with academic researchers.

We recently closed an oversubscribed funding round led by a top‑tier VC firm, giving us 3–4 years of runway at our current pace.

• 12.5 paid holidays
• PTO is three weeks annually, accruing at approximately 1.25 days per month
• Medical, Dental, and Vision
• Matching 401(k) plan
• Up to 12 weeks paid leave for new parents who are primary caregivers
• Tuition reimbursement for work‑related continuing education