Epigenetic Reprogramming Scientist - In Vitro Oogenesis

Ovelle; Boston, Northern (MA, KY); Hybrid; USD 120,000 - 190,000; Full time

Benefits offered by this job

12.5 paid holidays

PTO 3 weeks annually

Medical, Dental, Vision

Matching 401(k)

Up to 12 weeks paid parental leave

Tuition reimbursement for continuing教育

Job summary

Ovelle is a research-first startup advancing IVG by engineering epigenetic reprogramming in human iPSCs to produce eggs. You will lead genome-wide epigenetic profiling, build analytical toolkits, and develop strategies to master reprogramming beyond current protocols.

The role offers collaborative, cutting-edge research with a strong emphasis on reproducibility and publication. This position focuses on pushing the frontier of oogenesis, driving developmental competence of eggs, and contributing

Qualifications

• Deep knowledge of epigenetics and reprogramming in germ cells, embryos, or iPSCs.
• Hands-on human iPSC culture and related cell biology techniques.
• Proven genome engineering experience, including CRISPR knock-in/knockout.
• Experience with epigenetic profiling methods and multi-omics integration.
• Strong computational skills and ability to integrate bulk and single-cell data.
• PhD in stem cell biology, epigenetics, or related field, or equivalent work.

Responsibilities

• Lead genome-wide epigenetic reprogramming efforts during oogenesis.
• Develop and optimize tools to measure and benchmark epigenetic states.
• Engineer reprogramming strategies with inducible transcription factor circuits.
• Integrate epigenetic data with transcriptional programs to guide cell identity.
• Diagnose and address upstream molecular events causing abnormalities.
• Collaborate with teams and publish findings with the scientific community.

Skills

Epigenetics

iPSC culture

CRISPR engineering

Single-cell RNA-seq

Data analysis

Bioinformatics

Education

PhD in stem cell biology

Related field expertise

Tools

bisulfite sequencing

EM-seq

ChIP-seq

CUT&RUN

ATAC-seq

Hi-C

Job description

Ovelle is a research-first startup advancing IVG by engineering epigenetic reprogramming in human iPSCs to produce eggs. You will lead genome-wide epigenetic profiling, build analytical toolkits, and develop strategies to master reprogramming beyond current protocols.

The role offers collaborative, cutting-edge research with a strong emphasis on reproducibility and publication. This position focuses on pushing the frontier of oogenesis, driving developmental competence of eggs, and contributing