Enzyme Formulation Scientist (Process Development)

Moderna Therapeutics; Norwood, Northern (MA, KY); Hybrid; USD 109,000 - 175,000; Full time

Job summary

Moderna Therapeutics seeks a Scientist, Process Development (Formulation) to design and execute enzyme formulation studies for DNA template manufacturing. You will optimize buffers, pH, stabilizers, and storage conditions to preserve activity and enable scalable manufacturing.

The role requires hands-on formulation and stability work, DOE-driven study design, and collaboration across analytical and process development teams to translate functional requirements into robust, manufacturable

Qualifications

• PhD in Pharmaceutical Sciences, Chemical or Biochemical Engineering, or related field, or MS/BS with significant industry experience.
• Hands-on experience in protein/enzyme formulation development and stability.
• Experience with formulation screens, excipient compatibility, and forced degradation studies.

Responsibilities

• Design and execute enzyme formulation studies, optimizing buffers, pH, ionic strength, stabilizers, surfactants, and storage.
• Develop stability study designs evaluating activity, purity, degradation, aggregation, and process performance.
• Assess robustness under freeze/thaw, hold time, dilution, mixing, and contact-material exposure; connect to manufacturing outcomes.
• Use DOE and miniaturized models; collaborate with analytical and process development for transfer readiness.

Skills

Enzyme formulation

DOE design

Protein stability

Analytical assays

Cross-functional

Education

PhD in Pharmaceutical Sciences

MS with 5+ years

BS with 8+ years

Tools

Chromatography

DSF/DSC

Job description

Moderna Therapeutics seeks a Scientist, Process Development (Formulation) to design and execute enzyme formulation studies for DNA template manufacturing. You will optimize buffers, pH, stabilizers, and storage conditions to preserve activity and enable scalable manufacturing.

The role requires hands-on formulation and stability work, DOE-driven study design, and collaboration across analytical and process development teams to translate functional requirements into robust, manufacturable