Downstream Process Engineer

Indiana Ag Connection; Indianapolis, Northern (IN, KY); Hybrid; USD 110,000 - 160,000; Full time

Benefits offered by this job

Health benefits from day one

Paid time off (4 weeks)

Parental leave

Tuition reimbursement

Retirement plan

Job summary

Corteva Agriscience is seeking a Downstream Process Engineer to lead development and scale-up of downstream processes converting fermentation-derived materials into high-quality product streams, based in Indianapolis.

You will work within Bioprocess Discovery and Development and partner with fermentation, analytical, formulation, and scale-up teams to improve recovery, purity, yield, reliability, and transfer readiness.

Qualifications

• PhD in Chemical Engineering or MS with relevant industry experience.
• 3+ years of experience supporting scale-up, technology transfer, or manufacturing of fermentation-based products.
• Experience developing downstream processes for fermentation-derived or biological products.
• Knowledge of downstream unit operations of fermentation broth processing, including filtration, centrifugation, extraction, adsorption, chromatography, concentration, purification, and stabilization.
• Strong experimental design, data analysis, and technical communication skills.
• Ability to work independently and collaborate across multidisciplinary teams.
• Commitment to laboratory safety, documentation quality, and data integrity.
• Demonstrated success improving process performance, quality, scalability, or operational efficiency.

Responsibilities

• Design and execute downstream process development studies for fermentation-derived materials, including clarification, separation, extraction, filtration, concentration, and purification.
• Develop scalable recovery and purification strategies based on fermentation broth characteristics, product properties, and impurity profiles to cost targets.
• Optimize downstream processes to improve yield, product quality, throughput, reliability, and cost.
• Integrate fermentation performance, analytical results, and process data to guide development decisions.
• Apply experimental design and statistical analysis to efficiently solve technical challenges.
• Troubleshoot recovery, purification, stability, and scale-up issues.
• Lead downstream workstreams within cross-functional fermentation and process development programs.
• Support technology transfer and scale-up through process documentation, risk assessments, and manufacturing recommendations.
• Evaluate and implement new downstream technologies and tools to improve process understanding and efficiency.
• Prepare technical reports, presentations, and recommendations for project teams, capability leaders, and cross-functional stakeholders.
• Promote safe laboratory operations and continuous improvement practices.

Skills

Experimental design

Data analysis

Technical communication

Independent work

Cross-functional collaboration

Process development

Education

PhD in Chemical Engineering

MS with relevant industry experience

Tools

Statistical analysis software

Process modeling software

Data visualization tools

AI-enabled tools

Job description

# Downstream Process EngineerBack to search resultsApply to this positionFollow CompanyMore Jobs from Cortev...Send to Friend**Who are we, and what do we do?** At Corteva Agriscience, you will help us grow what's next. No matter your role, you will be part of a team that is building the future of agriculture - leading breakthroughs in the innovation and application of science and technology that will better the lives of people all over the world and fuel the progress of humankind.Corteva Agriscience has an opportunity for a Downstream Process Engineer. You will lead the development and scale-up of downstream processes that convert fermentation-derived materials into high-quality product streams. Working within Bioprocess Discovery and Development in Indianapolis, this role partners closely with fermentation, analytical, formulation, and scale-up teams to improve recovery, purity, yield, reliability, and transfer readiness. This position provides technical leadership in the development of recovery and purification processes for microbial products and fermentation-derived metabolites, applying sound experimental design, data analysis, and engineering principles to advance programs from laboratory development through scale-up. The engineer works with elevated independence, leads discrete downstream workstreams, and provides key mentorship to associate scientists to understand the upstream process context and material attributes that influence downstream performance and delivers sound science guiding clear technical recommendations.## ## **What You'll Do:*** Design and execute downstream process development studies for fermentation-derived materials, including clarification, separation, extraction, filtration, concentration, and purification.* Develop scalable recovery and purification strategies based on fermentation broth characteristics, product properties, and impurity profiles to cost targets.* Optimize downstream processes to improve yield, product quality, throughput, reliability, and cost.* Integrate fermentation performance, analytical results, and process data to guide development decisions.* Apply experimental design and statistical analysis to efficiently solve technical challenges.* Troubleshoot recovery, purification, stability, and scale-up issues.* Lead downstream workstreams within cross-functional fermentation and process development programs.* Support technology transfer and scale-up through process documentation, risk assessments, and manufacturing recommendations.* Evaluate and implement new downstream technologies and tools to improve process understanding and efficiency.* Prepare technical reports, presentations, and recommendations for project teams, capability leaders, and cross-functional stakeholders.* Promote safe laboratory operations and continuous improvement practices.**What Skills You Need:*** PhD in Chemical Engineering, Biochemical Engineering, Biotechnology, Chemistry, Industrial Microbiology, or related field; or MS with relevant industry experience.* 3+ years of experience supporting scale-up, technology transfer, or manufacturing of fermentation-based products in industry.* Experience developing downstream processes for fermentation-derived or biological products.* Knowledge of downstream unit operations of fermentation broth processing, including filtration, centrifugation, extraction, adsorption, chromatography, concentration, purification, and stabilization.* Strong experimental design, data analysis, and technical communication skills.* Ability to work independently and collaborate across multidisciplinary teams.* Commitment to laboratory safety, documentation quality, and data integrity.* Demonstrated success improving process performance, quality, scalability, or operational efficiency.## **Preferred Skills:*** Demonstration of several downstream processes from biologically derived actives developed into commercialized products* Experience with DoE, statistical analysis, process modeling, data visualization, or AI-enabled tools.* Experience leading technical workstreams and cross-functional project deliverables.#LI-BB1**Benefits - How We'll Support You:*** Numerous development opportunities offered to build your skills* Be part of a company with a higher purpose and contribute to making the world a better place* Health benefits for you and your family on your first day of employment* Four weeks of paid time off and two weeks of well-being pay per year, plus paid holidays* Excellent parental leave which includes a minimum of 16 weeks for mother and father* Future planning with our competitive retirement savings plan and tuition reimbursement program* Learn more about our total rewards package here - Corteva Benefits* Check out life at Corteva! www.linkedin.com/company/corteva/lifeAre you a good match? Apply today! We seek applicants from all backgrounds to ensure we get the best, most creative talent on our team.Corteva Agriscience is an equal opportunity employer. We are committed to embracing our differences to enrich lives, advance innovation, and boost company performance. Qualified applicants will be considered without regard to race, color, religion, creed, sex, sexual orientation, gender identity, marital status, national origin, age, military or veteran status, pregnancy related conditions (including pregnancy, childbirth, or related medical conditions), disability or any other protected status in accordance with federal, state, or local laws.To apply please click on APPLY TO THIS POSITIONApply to this position