Downstream Associate

SIGNOBIO INC; Houston (TX); On-site; USD 42,000 - 62,000; Full time

Benefits offered by this job

Free onsite parking

Free onsite gym

Career growth opportunities

World-class biotech campus

Job summary

Sino Biological Inc. in Houston, TX, is seeking an entry‑level Downstream Associate to support purification and quality control in a bioprocessing environment. You will perform chromatography‑based purification and QC testing under supervision, contributing to project timelines and product quality.

The role emphasizes meticulous documentation, collaboration across teams, and adherence to safety protocols. A bachelor’s degree in a related field and willingness to work flexible hours are required.

Qualifications

• Bachelor’s degree in Biology, Biochemistry, Biotechnology, or a related field.
• 0–3 years of relevant lab experience with basic protein purification knowledge.
• Familiarity with chromatography systems such as FPLC or HPLC.
• Experience with protein QC assays (SDS‑PAGE, HPLC‑SEC, endotoxin testing, ELISA) preferred.
• Strong documentation and organizational skills; ability to work cross-functionally.

Responsibilities

• Perform purification of recombinant proteins and antibodies using chromatography methods.
• Execute downstream workflows to meet project specifications and client requirements.
• Conduct protein QC tests (SDS‑PAGE, HPLC‑SEC, endotoxin assays, UV‑Vis) and analyze results.
• Maintain accurate batch records and lab notebooks per internal standards.
• Assist with calibration and maintenance of chromatography and analytical instruments.

Skills

Attention to detail

Documentation

Team collaboration

Communication

Education

Bachelor’s degree in Biology/Biochemistry/Biotechnology or related

Tools

FPLC/HPLC

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

Downstream Associate

Houston, TX, US

3 days ago Requisition ID: 1049

About Us

Sino Biological is an internationally recognized reagent supplier and contract research organization, listed on ChiNext of the Shenzhen stock exchange (301047 Sino Biological Inc.). Sino Biological's core technology platform is its in-house developed mammalian cell-based recombinant expression system, which employs proprietary reagents and processes for the efficient production of antigens and antibodies.

With its main manufacturing facilities in Beijing, China, Sino Biological also has a growing global presence with a US headquarters in the greater Philadelphia area, a bioprocessing facility in Houston, Texas, and subsidiaries in Frankfurt, Germany, and Tokyo, Japan.

As part of its major global expansion, the company has established the Center for Bioprocessing (C4B) in Houston, Texas, located in the world-renowned Texas Medical Center at Levit Green. This vibrant hub is home to some of the most cutting-edge innovation in biotechnology, offering our team an inspiring environment to do meaningful, impactful work in the heart of the medical and research community.

Job Description

This is an entry-level position suitable for individuals seeking hands‑on experience in protein purification and quality control in an industrial bioprocessing environment. The Associate will support the downstream team in executing purification workflows and conducting protein characterization assays to evaluate product quality. Responsibilities include chromatography‑based purification, recombinant protein QC related tasks under the guidance of project scientists. This role requires strong attention to detail, good lab documentation practices, and effective collaboration with cross‑functional teams.

Responsibilities

• Perform purification of recombinant proteins and antibodies from mammalian expression systems using chromatography methods and equipment (e.g., AKTA systems).
• Execute established downstream workflows to meet project specifications and client requirements.
• Conduct protein quality control testing, including SDS‑PAGE, HPLC‑SEC, endotoxin assays, UV‑Vis concentration measurement, and other analytical assays.
• Support lead scientists in preparing and analyzing QC data and interpreting protein quality results as part of downstream bioprocessing, including purification and quality control.
• Maintain accurate batch records, lab notebooks, and QC documentation in compliance with internal standards and client requirements.
• Ensure compliance with laboratory safety protocols and PPE usage in accordance with federal, state, and local regulatory guidelines.
• Assist with calibration, maintenance, and basic troubleshooting of chromatography and analytical instruments.
• Collaborate with other teams within the Center to support smooth project coordination and delivery.

Requirements

• Bachelor’s degree in Biology, Biochemistry, Biotechnology, or a related field.
• 0–3 years of relevant laboratory experience, with basic understanding of protein purification and analytical methods.
• Familiarity with chromatographic systems such as FPLC or HPLC used for protein purification.
• Experience or exposure to protein QC analytical assays, such as SDS‑PAGE, HPLC‑SEC, and endotoxin testing and ELISA.
• Strong organizational and documentation skills, with attention to detail.
• Willingness to work a flexible schedule, including early/late weekday shifts and occasional weekend work depending on project needs.
• Good communication skills and a collaborative team mindset.
• Flexibility is required, including potential weekend work and early or late weekday shifts based on project demands.
• Must be able to lift and move 25–50 lbs as needed.
• At this time, we are unable to provide visa sponsorship. Applicants must be legally authorized to work in the United States now and in the future without the need for sponsorship.

Why Join Us at C4B?

Working at Sino Biological’s C4B facility isn’t just another lab job — it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:

• World‑class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.
• Beautiful work environment: Enjoy a brand‑new, state‑of‑the‑art facility designed for collaboration and scientific excellence.
• Free onsite parking: Skip the hassle and expense of parking in the Medical Center — we’ve got you covered.
• Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.
• Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.
• Supportive team culture: A welcoming, team‑first workplace that values diversity, collaboration, and professional development.

Note:

Only shortlisted candidates will be contacted for interviews. If selected, an HR team member will reach out to schedule a quick phone interview using the contact information provided in your resume.

Sino Biological Inc. is an equal‑opportunity employer. We celebrate diversity and are committed to building an inclusive environment for all employees.