Director, Translational Medicine (Inflammation)

ALLInBio, Inc.; Palo Alto (CA); Hybrid; USD 260,000 - 420,000; Full time

Benefits offered by this job

Competitive compensation

Science-first culture

Leadership visibility

Job summary

ALLInBio, Inc. is seeking an experienced Director of Translational Medicine (Inflammation) to bridge discovery, preclinical work, and early clinical programs. You will own translational strategies, biomarker development, and clinical readiness, while leading cross-functional teams in a fast-paced startup setting.

The role emphasizes hands-on leadership, biomarker-focused decision making, and close collaboration with research, regulatory, and clinical operations to accelerate the pipeline.

Qualifications

• 10+ years in biotech/pharma translational medicine with leadership experience.
• Experience directing CROs for assays development and biomarker work.
• Strong background in immunology, inflammation, human disease biology, and translational biomarkers.
• Experience with IND/CTA-enabling activities and early-phase clinical development.
• Proven scientific publications or patents.

Responsibilities

• Lead translational medicine strategies across preclinical and early clinical programs, aligning mechanism, biomarkers, and clinical hypotheses.
• Define and drive biomarker strategies across discovery to clinical stages, including PD, predictive, and exploratory biomarkers.
• Integrate human biology and disease pathophysiology to inform target validation, indication selection, dose rationale, and development plans.
• Collaborate with research, clinical development, regulatory, and external partners to translate preclinical work to patients.
• Lead translational contributions to IND/CTA-enabling activities and clinical protocols.
• Oversee CROs and academic collaborators for translational studies and biomarker development.
• Interpret complex datasets to inform program decisions and strategy.
• Represent translational medicine on cross-functional teams and communicate rationale, risks, and opportunities to leadership.
• Contribute to publications, conferences, and IP in translational and biomarker efforts.
• Build scalable translational processes and contribute to company growth, culture, and operational excellence.

Skills

Leadership

Translational biology

Biomarker strategy

IND/CTA enablement

Regulatory collaboration

Cross-functional teamwork

Communication

Problem solving

Startup/matrix environment

Education

PhD, MD, or MD/PhD in biomedicine

Job description

Director, Translational Medicine (Inflammation)

Location

Virtual-but-local model: candidates may work remotely but must be available for

weekly in-person meetings at our Palo Alto headquarters.

Company Overview

We are a clinical-stage biotechnology company focused on developing innovative

therapies for patients with serious unmet medical needs, with an emphasis on

autoimmune and inflammatory diseases. We operate in a fast-paced, highly

collaborative, and science-driven environment, and value entrepreneurial individuals

who enjoy building processes, solving complex problems, and contributing hands-on to

the advancement of clinical programs.

Role Summary

We are seeking an experienced translational medicine leader to bridge discovery,

preclinical development, and early clinical programs. The person will own the

translational strategies that enable efficient progression of our pipeline from mechanism

to patients, with a strong emphasis on biomarker strategy, human disease relevance,

and clinical readiness.

This role is ideal for a leader who thrives in a dynamic startup environment, enjoys

working across scientific disciplines, and wants to combine strategic leadership with

direct, hands-on contributions to translational execution across our programs.

Key Responsibilities

• Lead and execute translational medicine strategies to support preclinical and early clinical programs, ensuring alignment between mechanism, biomarkers, and clinical hypotheses
• Define and drive biomarker strategies across discovery, IND/CTA-enabling, and clinical stages, including pharmacodynamic, predictive, and exploratory biomarkers
• Integrate human biology, disease pathophysiology, and preclinical data to inform target validation, indication selection, dose rationale, and clinical development plans
• Partner closely with research, clinical development, clinical operations, regulatory, and external collaborators to ensure seamless translation from preclinical models to patients
• Lead translational contributions to IND/CTA-enabling activities, including the translational sections of regulatory submissions and clinical protocols
• Oversee and manage external CROs and academic collaborators supporting translational studies and biomarker development
• Analyze and interpret complex datasets (preclinical, translational, and early clinical) to inform program decisions and development strategy
• Represent translational medicine on cross-functional program teams and clearly communicate translational rationale, risks, and opportunities to senior leadership
• Contribute to scientific publications, conference presentations, and intellectual property related to translational and biomarker efforts
• Build scalable translational medicine processes and contribute to the growth, culture, and operational excellence of the organization

Required Qualifications

• PhD, MD, or MD/PhD in a relevant biomedical or life sciences discipline with 10+ years of relevant experience in the biotech and/or pharmaceutical industry,
• including prior Director-level or equivalent leadership experience
• Demonstrated track record of leading translational strategies that bridge preclinical research and early clinical development, including directing CROs to
• develop and run assays
• Deep understanding of immunology, inflammation, human disease biology, and translational biomarkers; experience in rheumatoid arthritis and/or fibrosis is a
• Experience leading IND/CTA-enabling activities and early-phase clinical
• Strong interpretive and hypothesis-generation skills, paired with demonstrated ability to analyze large omics datasets
• Creative, discovery-oriented mindset, with a proven ability to work effectively in multidisciplinary, fast-moving, matrixed team environments
• Highly self-motivated, execution-driven, and scientifically rigorous
• Proven record of scientific contributions, including publications and/or patents
• Prior experience in a startup or small biotech environment
• Strong translational and integrative scientific thinking
• Excellent organizational and project management skills
• Clear and effective communicator with the ability to influence across functions
• Proactive problem-solver who is comfortable operating in ambiguity
• Team-oriented leader with a strong sense of ownership and accountability
• Hands-on mindset balanced with strategic perspective

Why Join Us

• Opportunity to shape and lead translational strategy across our pipeline
• Leadership role with a high level of responsibility and scientific influence in a growing startup
• Collaborative, rigorous, and science-first culture
• Competitive compensation and benefits