Senior Scientist

Triana Biomedicines Inc.; Lexington (MA); On-site; USD 130,000 - 145,000; Full time

Job summary

TRIANA Biomedicines Inc. is seeking an experienced immunologist to advance discovery programs by linking target degradation to disease-relevant immunological outcomes.

You will design robust assays, study target biology in human immune cells, and coordinate in vivo pharmacology studies with CRO partners in autoimmune models. The ideal candidate has deep molecular and cellular biology expertise, strong translational biology instincts, and a track record of driving programs toward in vivo proof of

Qualifications

• Track record advancing discovery-stage immunology and inflammation programs to in vivo proof of concept.
• Extensive hands-on molecular and cellular biology expertise including gene knockout/knockdown, signaling, and downstream readouts.
• Experience with rodent models of autoimmune/inflammatory disease and in vivo data interpretation.

Responsibilities

• Assay Development: Design, develop and implement robust disease relevant cell-based assays to assess target engagement, protein degradation, and downstream pathway modulation.
• Mechanistic Biology: Design and execute experiments that connect target degradation to phenotypic response in primary human immune cells and in validated in vivo models of autoimmune disease.
• In Vivo Pharmacology: Design, manage and interpret in vivo studies conducted with external partners in rodent models of autoimmune and inflammatory disease, including PK/PD and efficacy studies.
• Data Generation & Interpretation: Identify critical project questions and produce high-quality datasets that guide stage-appropriate program decisions.
• Collaboration and Communication: Distill complex biological data into clear insights and communicate findings effectively across functions.

Skills

CRISPR/Cas9

RNAi

cell culture

lentiviral systems

qRT-PCR

flow cytometry

cytokine profiling

proliferation assays

cell signaling

pathway analysis

transfection

immunoblotting

Education

Ph.D. in Immunology or related

BS/MS with 12+ years in industry

Job description

Description

About TRIANA Biomedicines

TRIANA Biomedicines is a Greater Boston biotechnology company building the leading molecular glue discovery platform to regulate disease targets that are difficult to address with any other modality. TRIANA’s drug discovery engine is powered by high-resolution structural insights, state-of-the-art AI and computational tools, and bespoke chemical libraries.

TRIANA’s target-first and rational approach to molecular glue discovery is currently focused on inducing or enhancing the degradation of high-profile cancer targets. The therapeutic approach pioneered by TRIANA has the potential to fundamentally change the paradigm of small molecule drug discovery and bring significant therapeutic benefits to patients. TRIANA is a private company with a top-tier investor syndicate.

We are seeking an experienced immunologist with deep in vitro and in vivo pharmacology expertise to join our Biology and Translational Sciences group. This role is central to advancing discovery programs from hit validation on by establishing clear mechanistic and translational links between target degradation and disease-relevant immunological outcomes in autoimmune and inflammatory disease.

We are looking for a scientifically rigorous, highly accountable individual who thrives in a fast-paced biotech environment and is motivated by generating decisive data that drives program progression.

Responsibilities

• Assay Development: Design, develop andimplement robust disease relevant cell-based assays to assess target engagement, protein degradation, and downstream pathway modulation.
• Mechanistic Biology: Design and execute experiments that connect target degradation to phenotypic response in primary human immune cells and in validated in vivo models of autoimmune disease.
• In Vivo Pharmacology: Design, manage and interpret in vivo studies conducted with external partners in rodent models of autoimmune and inflammatory disease (e.g., rheumatoid arthritis), including PK/PD and efficacy studies, and translate target degradation and pharmacodynamic readouts into disease-relevant endpoints.
• Data Generation & Interpretation: Identify critical project questions and produce high-quality, actionable datasets that guide stage-appropriate program decisions.
• Collaboration and Communication: Distill complex biological data into clear insights and communicate findings effectively to cross-functional partners and leadership; maintain thorough and accurate experimental documentation.

Qualifications

• Demonstrated track record advancing discovery-stage immunology and inflammation programs to in vivo proof of concept in a biotech or pharmaceutical environment.
• Extensive hands-on expertise in molecular and cellular biology, including cell culture, gene knockout and knockdown approaches (e.g., CRISPR/Cas9, RNAi), transfection and lentiviral systems, cell signaling and pathway analysis, immunoprecipitation/immunoblotting, qRT-PCR, and proliferation or viability assays.
• In-depth experiencewith rodent models of autoimmune and inflammatory disease (e.g., collagen- or adjuvant-induced arthritis, humanized or adoptive transfer models), spanning study design, dosing regimens, and interpretation of disease and pharmacodynamic readouts, including ex vivo immunophenotyping; comfortable overseeing CRO-run studies and interpreting clinical scoring andhistopathology data.
• Solid immunology expertise across innate and adaptive immunity, with hands-on flow cytometry, primary immune cell isolation and culture, cytokine profiling, and immune functional assays.
• Clear, effectivecommunicator who collaborates across scientific disciplines and presents rigorous analyses that support informed program decisions.
• Familiarity with targeted protein degradation or molecular glue mechanisms preferred; experience supporting IND-enabling studies in autoimmunity is a plus.

Education & Experience

Ph.D. in Immunology, Immunobiology, or a related discipline with 6+ years of post-graduate experience (industry experience preferred) or B.S./M.S. with 12+ years of industry experience.

We welcome applications from skilled individuals whose qualifications may not fit the criteria outlined above.

Base Salary Range: $130-$145k

Our Culture

Our Team is our greatest asset at TRIANA. We are proud to work with an integrated group of individuals from an extensive range of backgrounds and experiences. Diversity, Equity, Inclusion and Belonging are important aspects of our culture. We embrace our differences and cultivate an environment that drives better collaboration and innovation by striving to ensure that all coworkers have an ongoing positive experience while being their authentic selves.

Our Values

At TRIANA we are empowered to act. We dare to create transformative medicines for patients. Our creativity and dedication are the glue that unites us in pursuit of our mission.

Thank you for your interest in TRIANA!