Director, Oncology PK/PD Modeling & Simulation

GSK; Durham (NC); Hybrid; USD 188,000 - 314,000; Full time

Benefits offered by this job

Health benefits

Annual bonus

Retirement plan

Job summary

GSK is seeking a Director to join the CPMS Oncology group within Oncology Translational Medicine. You will lead quantitative pharmacology efforts to optimize dosing and accelerate development of oncology therapies.

Hybrid on-site policy with 2–3 days/week in the office in the US. You will work on antibody-drug conjugates, biologics, and small molecules, delivering model-based analyses that inform clinical programs and regulatory submissions.

Qualifications

• PhD or equivalent in quantitative pharmacology or related field.
• 5+ years using population PK and exposure–response modelling in drug development.
• 3+ years planning and reporting model-based analyses per regulatory standards.

Responsibilities

• Define and execute model-based development strategies for oncology projects.
• Plan, conduct, and report population PK and exposure–response analyses; design dose selection.
• Present strategies to governance boards and regulatory agencies.

Skills

Modeling & Simulation

Population PK

Exposure-Response

Pharmacometric Tools (NONMEM, R)

Oncology Drug Development

MID3 (Model-Informed)

Leadership & Collaboration

AI/ML in Pharmacometrics

Education

PhD in Quantitative Clinical Pharmacology/Pharmacometrics

PharmD or Master’s in related field

Tools

NONMEM

R

Job description

GSK is seeking a Director to join the CPMS Oncology group within Oncology Translational Medicine. You will lead quantitative pharmacology efforts to optimize dosing and accelerate development of oncology therapies.

Hybrid on-site policy with 2–3 days/week in the office in the US. You will work on antibody-drug conjugates, biologics, and small molecules, delivering model-based analyses that inform clinical programs and regulatory submissions.