Executive Director, Oncology Clinical Pharmacology Modeling

GSK; Collegeville (PA); On-site; USD 250,000 - 350,000; Full time

Benefits offered by this job

Health care benefits

Retirement benefits

Paid holidays

Paid caregiver/parental leave

Job summary

GSK seeks an Executive Director for Oncology Clinical Pharmacology Modeling and Simulation (CPMS) in the US. This role provides scientific leadership in trial design, PK/PD modeling, and regulatory submissions, aligning translational science with clinical development.

The position requires on-site presence 2–3 days/week and leadership of a matrix team across PK/PD, MS, and clinical pharmacology, with collaboration to accelerate oncology programs and global harmonization of pre-clinical to

Qualifications

• PhD with 15+ years in biotech/pharma or related industry.
• 15+ years in drug development functions (Nonclinical and Clinical).
• 5+ years managing matrix teams, external providers and consultants.
• Hands-on PK/PD data analysis and advanced modeling/simulation (Population PK, PBPK).
• Experience in translational research and clinical pharmacology in ADCs, TCEs, small molecules and antibodies.

Responsibilities

• Provide advanced technical, therapeutic, and product development support for oncology programs.
• Provide managerial support to CPMS Managers and Directors; optimize PK/PD, modeling and simulation applications.
• Bridge clinical pharmacology and modeling/simulation to development programs.
• Design clinical pharmacology studies (e.g., rBA/BE, DDI, special populations, human ADME, TQT).
• Develop efficient modeling strategies including PBPK to support trial design and dosing justification.
• Contribute to regulatory dossiers (INDs, IBs, briefing packages).
• Engage with regulatory authorities as needed.
• Lead talent development and succession planning within CPMS.

Skills

Animal Models, AI & ML

Clinical Pharmacology

Drug Design

Pharmacokinetics (PK)

Pharmacodynamics (PD)

Modeling & Simulation

Oncology

Regulatory Submissions

Education

PhD in biological/pharmaceutical sciences

Job description

GSK seeks an Executive Director for Oncology Clinical Pharmacology Modeling and Simulation (CPMS) in the US. This role provides scientific leadership in trial design, PK/PD modeling, and regulatory submissions, aligning translational science with clinical development.

The position requires on-site presence 2–3 days/week and leadership of a matrix team across PK/PD, MS, and clinical pharmacology, with collaboration to accelerate oncology programs and global harmonization of pre-clinical to