Director of Protein Engineering & Discovery Strategy

Bristol-Myers Squibb Co; Virginia; On-site; USD 200,000 - 300,000; Full time

Benefits offered by this job

Comprehensive benefits

Flexible time off

11 paid company holidays

Job summary

Bristol Myers Squibb Co. seeks a Director of Protein Engineering to guide the design and optimization of therapeutic proteins across discovery programs.

You will lead a team of engineers, set strategies, and partner with ML and computational groups to drive molecules from concept to development candidate nomination. In this role you will align formats and modalities with biology and patient needs, ensuring development readiness and manufacturability across expression, purification, and

Qualifications

• PhD/MS/BA with extensive protein engineering experience.
• Experience leading discovery programs and cross‑functional teams.
• Deep expertise in therapeutic protein engineering and antibody formats.
• Proven ability to drive programs from concept to development.
• Strong written and verbal communication; ability to influence stakeholders.

Responsibilities

• Lead the protein engineering team and set scientific direction.
• Own engineering strategy from concept to development candidate nomination.
• Collaborate with ML and computational leaders on design strategy.
• Align engineering plans with therapeutic area priorities and product profiles.
• Ensure developability and manufacturability of designed molecules.

Skills

Leadership

Protein engineering

Structure-function

Biologics design

Communication

Cross-functional

Education

PhD in relevant field

MS in relevant field

Tools

Rosetta

FoldX

MOE

Schrödinger

PyMOL

Job description

Bristol Myers Squibb Co. seeks a Director of Protein Engineering to guide the design and optimization of therapeutic proteins across discovery programs.

You will lead a team of engineers, set strategies, and partner with ML and computational groups to drive molecules from concept to development candidate nomination. In this role you will align formats and modalities with biology and patient needs, ensuring development readiness and manufacturability across expression, purification, and