Director of Information Technology

BBOT; South San Francisco (CA); Hybrid; USD 222,000 - 250,000; Full time

Job summary

A leading biotech company in South San Francisco is seeking a Director of IT to oversee technology functions during a pivotal pre-IPO phase. The role involves strategic IT leadership, compliance readiness, and vendor management. Candidates should have extensive IT experience, particularly in regulated environments, and possess strong leadership skills. This hybrid position offers competitive compensation and the opportunity to shape the company's IT landscape.

Benefits

Competitive salary

Annual performance bonus

Company equity

Generous health benefits

Qualifications

• 7-10 years of IT experience in biotech or life sciences.
• Experience building secure IT infrastructure in GxP and SOX environments.

Responsibilities

• Develop and execute IT strategy aligned with business goals.
• Oversee IT infrastructure maintenance, security, and scalability.
• Implement cybersecurity best practices and manage IT helpdesk services.

Skills

Leadership

Problem Solving

Communication

Tools

AWS

Azure

O365

OKTA

Job description

BridgeBio Oncology Therapeutics (“BBOT”) is a private biotech company focused on developing innovative therapies to address urgent unmet needs in oncology. Founded on a patient-first philosophy, scientific excellence, and operational agility, BBOT is committed to transforming the lives of people living with cancer. Led by a team of experienced scientists, clinicians, and industry experts, BBOT leverages cutting-edge, structure-based drug discovery techniques to tackle some of the most challenging and validated molecular targets in oncology, including KRAS and PI3Kα. With a promising pipeline of differentiated drug candidates and robust investor backing, BBOT is uniquely positioned to deliver meaningful impact to patients. Headquartered in South San Francisco, BBOT’s team spans the U.S. and the globe. To learn more, visit bridgebiooncology.com

Position Summary:

The Director of IT will oversee all aspects of the company’s technology function—including infrastructure, cybersecurity, cloud services, enterprise applications, and end-user support—at a pivotal moment as we prepare for a public listing. This role requires a hands-on leader who can balance daily operations with strategic readiness for SOX compliance, ITGC controls, and scalable growth. This is a new role in a lean, execution-focused biotech environment (~50–100 employees). The Director will directly manage external vendors and consultants while building internal IT capabilities over time.

Key Responsibilities:

• IT Strategy & Leadership: Develop and execute an IT strategy aligned with business goals, supporting R&D, regulatory compliance, and corporate growth.
• deSPAC & Public Readiness: Lead implementation of ITGC controls, audit-ready documentation standards, change management policies, and evidence collection in support of SOX and SEC compliance. Coordinate closely with auditors, legal, and finance to ensure IPO readiness.
• Infrastructure & Operations: Oversee the maintenance, security, and scalability of IT infrastructure, including networks, cloud services, and on-premises systems.
• Cybersecurity & Compliance: Implement cybersecurity best practices, identity and access management (IAM) protocols, role-based access controls (RBAC), and data classification standards. Maintain incident response plans and business continuity processes aligned with ISO/NIST frameworks.
• User Support & Productivity: Manage IT helpdesk services, providing high-quality support to researchers, scientists, and corporate users.
• Enterprise Applications: Administer and optimize business applications such as Laboratory Systems, Finance, Procurement, R&D and collaboration tools.
• GxP Systems Support: Collaborate with QA/Regulatory to maintain validated systems supporting GxP functions (e.g., LIMS, eTMF, CTMS).
• Cloud & Data Management: Oversee cloud-based services, data storage, backup, and disaster recovery planning.
• IT Governance & Budgeting: Establish IT policies, best practices, and budget planning for technology investments.
• Vendor & Stakeholder Management: Evaluate, negotiate, and manage relationships with third-party vendors, service providers, and software suppliers.

Qualifications & Experience:

• 7-10 years of IT experience, preferably within the biotech, pharmaceutical, or life sciences sector.
• Demonstrated experience building and scaling secure IT infrastructure in GxP and SOX environments.
• Strong understanding of ITGCs, audit preparation, SOX documentation, and regulated environments.
• Familiarity with GxP, HIPAA, GDPR, FDA 21 CFR Part 11, and ISO 27001 frameworks.
• Deep knowledge of cloud platforms (AWS, Azure, O365, OKTA), IAM tools, and secure collaboration environments.
• Experience with laboratory, finance, and R&D systems common in clinical-stage biotech companies.
• Hands-on, pragmatic problem-solver who thrives in ambiguity and can scale IT intelligently without overengineering.
• Hands-on experience in IT security, networking, and troubleshooting.
• Strong problem-solving, strategic thinking, and leadership skills.
• Excellent communication skills with the ability to engage both technical and non-technical stakeholders.

Work Location

This role is based in South San Francisco, CA and operates in a hybrid capacity, with an expected 2-3 days per week onsite. Flexibility may be considered for exceptional candidates with deep public company or biotech experience.

Why Join Us?

• Join a fast-paced, mission-driven biotech team focused on delivering transformational therapies
• Play a pivotal role in building the company’s IT function during a critical pre-IPO period—with direct exposure to executive leadership and board-level initiatives.
• Competitive salary, benefits, and meaningful equity participation in a company entering the public market

At BridgeBio Oncology Therapeutics (BBOT), we strive to provide a market-competitive total rewards package, including base pay, an annual performance bonus, company equity, and generous health benefits. Below is the anticipated salary range for candidates for this role who will work in California. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the type and length of experience within the job, type, and length of experience within the industry, educational background, location of residence and performance during the interview process. BridgeBio Oncology Therapeutics (BBOT) is a multi-state employer, and this salary range may not reflect positions based in other states.

$222,000 - $250,000 USD

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