DEL Discovery Chemist — DNA-Encoded Library Platform

Nurix Therapeutics; Brisbane (CA); On-site; USD 119,000 - 139,000; Full time

Job summary

Nurix Therapeutics Brisbane is seeking a talented chemist to join the Discovery Chemistry team and help design and synthesize DNA-encoded libraries (DELs). The role sits at the interface of chemistry, biology and automation, with opportunities to shape the DEL lead-discovery platform.

You will design DEL libraries, validate new transformations, and collaborate across teams to advance DEL screening and hit-optimization. Required: a B.S.

Qualifications

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry with 5 years of industrial experience.
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA encoded libraries.
• Familiar with the DNA-Encoded Library Technology workflow.

Responsibilities

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
• Construct DEL libraries to support the in‑house library production efforts.
• Work with external partners to support our DEL synthesis and hit follow up strategies.
• Engage in cross‑functional team discussions that support DEL screening, data analysis, machine learning and hit‑optimization.
• Contribute to platform automation and technology development efforts.
• Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Skills

DNA-Encoded Library Technology

Synthetic Organic Chemistry

LCMS/HPLC analysis

Cross-functional collaboration

Education

B.S. or higher in Chemistry/Biochemistry/Medicinal Chemistry

Job description

Nurix Therapeutics Brisbane is seeking a talented chemist to join the Discovery Chemistry team and help design and synthesize DNA-encoded libraries (DELs). The role sits at the interface of chemistry, biology and automation, with opportunities to shape the DEL lead-discovery platform.

You will design DEL libraries, validate new transformations, and collaborate across teams to advance DEL screening and hit-optimization. Required: a B.S.