DEL Discovery Chemist - DNA-Encoded Libraries

BioSpace; Brisbane (CA); On-site; USD 119,000 - 139,000; Full time

Job summary

Nurix Therapeutics, Inc. in Brisbane, CA seeks a Senior Research Associate to advance DNA-encoded library technologies within our Discovery Chemistry group.

You will design DEL library concepts, synthesize libraries, and collaborate with biology, data science, and automation teams to push DEL-based lead discovery forward. You will contribute to automation efforts, present findings, and help translate DEL innovations into practical screening and hit‑optimization strategies.

Qualifications

• BS or higher in Chemistry, Biochemistry, or Medicinal Chemistry with 5 years of industrial experience.
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA encoded libraries.
• Familiar with the overall DNA-Encoded Library Technology workflow operations.
• Experience analyzing and purifying DNA-conjugates using LCMS/HPLC.
• Experience working in drug discovery, including design, synthesis, and SAR-based hit-to-lead optimization.
• Experience with high-throughput analytical and purification systems for DEL applications.
• Experience with molecular biology tools (PCR, qPCR, Western Blot).

Responsibilities

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations to widen DEL space.
• Construct DEL libraries to support in-house production.
• Collaborate with external partners on DEL synthesis and hit follow-up.
• Engage in cross-functional discussions supporting DEL screening, data analysis, and hit optimization.
• Contribute to platform automation and technology development.
• Present results and document workflows for scientific and strategic planning.

Skills

DNA-encoded libraries

Organic synthesis

LCMS/HPLC

Drug discovery

Education

B.S. or higher in Chemistry/Biochem/Medicinal Chemistry with 5 years industry

Tools

PCR

qPCR

Western Blot

Job description

Nurix Therapeutics, Inc. in Brisbane, CA seeks a Senior Research Associate to advance DNA-encoded library technologies within our Discovery Chemistry group.

You will design DEL library concepts, synthesize libraries, and collaborate with biology, data science, and automation teams to push DEL-based lead discovery forward. You will contribute to automation efforts, present findings, and help translate DEL innovations into practical screening and hit‑optimization strategies.