Computational Biologist, Lung Regeneration & Modeling

Unither Pharmaceuticals; Silver Spring (MD); On-site; USD 125,000 - 150,000; Full time

Job summary

United Therapeutics seeks a Computational Biologist, Cellularization to develop multiscale lung models and support in silico design of manufactured organs. You will bridge biology, mathematics and engineering to create predictive insights guiding experimental testing.

You will apply mechanistic modeling, collaborate with experimental scientists, and communicate results via visualizations and peer-reviewed publications as part of CLIMB’s effort to model cellular processes in 3D-printed lung

Qualifications

• Master’s Degree in biomedical engineering, computational biology, applied mathematics, or related field of study and 6+ years of industry experience developing computational models of biological systems with a master’s degree OR 2+ years of industry experience developing computational models of biological systems with a PhD.
• Experience with cell-based modeling and simulation software packages (e.g. Morpheus, CompuCell3D)
• Fluency in one or more scientific programming languages (e.g. Python, R, Julia)
• Knowledge of molecular and cellular biology and drug development
• Ability to communicate effectively with both technical and non-technical audiences as demonstrated by record of presentations and publications

Responsibilities

• Develop mathematical models of cellular processes in the lung, including but not limited to cell division, migration, and adhesion, with modulation by the mechanical and chemical environment based on published models and extensions developed in-house to analyze experimental data from cellularization of 3D-printed scaffolds with endothelial, epithelial, and other cell types
• Establish iterative cycle of experimental design based on hypotheses generated by mathematical models to assist with development of new cellularization approaches
• Implement procedures for model qualification to evaluate impact of uncertainty and variability on model output and consequent impact on experimental design
• Collaborate with other computational biologists and engineers to integrate cell-based models into large multiscale models spanning processes from organ to molecular level
• Partner with internal and external labs to better understand the needs of experimental scientists and coordinate the generation of experimental data for model training/validation
• Communicate results effectively through interactive visualizations and presentations at internal and external meetings and publishing in peer-reviewed journals
• Perform other duties as assigned

Skills

Biological modeling

Python

Numerical methods

Agent-based models

PDEs/ODEs

Scientific programming

Education

Master's degree in biomedical engineering or related field

PhD preferred

Tools

Morpheus

CompuCell3D

Job description

United Therapeutics seeks a Computational Biologist, Cellularization to develop multiscale lung models and support in silico design of manufactured organs. You will bridge biology, mathematics and engineering to create predictive insights guiding experimental testing.

You will apply mechanistic modeling, collaborate with experimental scientists, and communicate results via visualizations and peer-reviewed publications as part of CLIMB’s effort to model cellular processes in 3D-printed lung