CMC Program Manager

Immatics; Houston (TX); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Health Insurance

Vacation PTO

Life Insurance

Disability Insurance

401(k) Match

Parental Leave

Voluntary Benefits

Job summary

Immatics is seeking a Program Manager, CMC to lead cross-functional activities across manufacturing, analytical, quality, regulatory, and supply chain in cell therapy development. You will drive plans, milestones, risk, and readiness for regulatory submissions and commercial manufacturing.

Reporting to the Director, Program Management, you will coordinate with external vendors and internal teams to ensure alignment and timely execution.

Qualifications

• Bachelor's degree in life sciences, medicine, immunology, oncology, or related field.
• 5+ years in biotech/pharma/oncology clinical development environments.
• CMC programs experience across manufacturing, quality, analytical, regulatory operations.
• Academic or industry experience in cell and gene therapy, immunology/oncology, or bioprocessing/manufacturing sciences.

Responsibilities

• Develop and maintain CMC program plans, timelines, risk registers, trackers, and reporting tools.
• Manage CMC deliverables, milestones, and critical paths aligned with development timelines.
• Lead cross-functional CMC meetings with agenda, documentation, and action tracking.
• Drive collaboration across Manufacturing, Process Development, Analytical Development, Quality, Regulatory, Supply Chain, and Patient Operations.
• Coordinate activities with external vendors, CMOs, CDMOs, and contractors.
• Support governance and decision-making with department leaders and senior management.
• Contribute to continuous improvement of CMC program management tools and onboarding processes.

Skills

CMC Programs

Cross-functional coordination

Regulatory operations

Project management

Cell therapy

Education

Bachelor's degree in life sciences

Tools

PM dashboards

Regulatory reporting systems

Job description

JoinImmaticsandshape thefuture ofcancerimmunotherapy; one patient at atime!

Immaticsis committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting ofPRAME, a target expressed in more than 50 cancers. Ourcutting-edgescience and robust clinical pipeline form the broadestPRAMEfranchise with the mostPRAMEindications and modalities, spanning TCR T-cell therapies and TCRbispecifics.

Why Join Us?

• Innovative Environment:Helptopioneeradvancementsincancer immunotherapy.
• Collaborative Culture:Be part ofa diverse team dedicated to yourprofessionalgrowth.
• Global Impact:Contribute to therapiesthatmakealastingimpactonpatientsglobally.

Role Overview

We are seeking a Program Manager, CMC to lead and coordinate cross-functional Chemistry, Manufacturing, and Controls (CMC) activities within a cell therapy development and manufacturing environment. The Program Manager, CMC will drive planning, execution, and integration across manufacturing, analytical, quality, regulatory, and supply chain functions to support clinical development and commercialization goals. This role serves as a strategic partner across technical and operational teams, ensuring alignment, proactive risk management, and readiness for key milestones, including regulatory submissions and commercial manufacturing.

Reports to

Director, Program Management

Location

13203 Murphy Road Suite 100 Stafford, TX 77477

Basic Qualifications

• Bachelor's degree in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related field
• 5+ years of experience within biotechnology, pharmaceutical, or oncology-focused clinical development environments
• Demonstrated experience in CMC programs and projects working cross-functionally within CMC activities, including manufacturing, quality, analytical, and regulatory operations
• Academic or industry experience in cell and gene therapy, immunology/oncology, or bioprocessing/manufacturing sciences

Preferred Qualifications

• Advanced degree such as a Masters or PhD in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related field
• Experience supporting late-stage CMC programs in immunology, oncology, or cell and gene therapy
• Proven experience managing programs and critical paths across multiple technical and operational functions
• Proficiency with project management tools, dashboards, and reporting systems in regulated environments
• Proven leadership, stakeholder management, and organizational skills with the ability to manage competing priorities in fast-paced environments
• An ability to identify risks, drive decision-making, and implement process improvements across cross-functional teams
• Experience coordinating external vendors, CMOs, CDMOs, or consulting partners
• Strong communication and presentation skills with experience supporting senior leadership discussions and strategic planning

In This Role You Will

• Develop and maintain CMC program plans, timelines, risk registers, trackers, and reporting tools to support integrated program execution
• Manage CMC deliverables, milestones, and critical paths while ensuring alignment with overarching development program timelines
• Lead and facilitate cross-functional CMC meetings, including agenda development, documentation, action tracking, and follow-up activities
• Drive collaboration across Manufacturing, Process Development, Analytical Development, Quality, Regulatory, Supply Chain, and Patient Operations teams
• Coordinate and oversee activities with external vendors, contractors, CMOs, and CDMOs
• Support strategic planning, governance, and decision-making activities with department leaders and senior management
• Contribute to continuous improvement of CMC program management tools, processes, onboarding, and operational best practices

What do we offer?

AtImmatics, we believe in investing in our team’s health,safetyand well-being.Here’swhat you can expectif youjoinImmatics

Comprehensive Benefits

• Competitive rates forHealth, Dental, and Vision Insurance
• 4 weeksofvacation,grantedup front each year and prorated for firstand lastyearofemployment.
• 12 company paid holidays
• 7daysof sick time
• 100%employer-paidlifeinsuranceup toat 1x annual salary, up to one hundred thousand dollars
• 100%employer-paidshort-andlong-Termdisabilitycoverage
• 401(k)withimmediateeligibilityandcompany match. The company will match100% of your contributions upto3% of yourbase salaryfor the first two yearsof employment, 4% foryears 2-3 of employment, and up to5%of your salaryfrom the fourth year onward of continued employment.
• Partiallypaidparentalleavefor eligible employees.
• Additionalvoluntaryemployee-paidbenefitsandservices,includingaccident,hospitalindemnity,andcriticalillnessinsurance,as well asidentitytheftprotectionandpetinsurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard torace, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexualorientation, gender identity or expression, national origin, ancestry, age, marital status, disability, geneticinformation, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants withsincerely heldreligious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us [e-mail].

Work Authorization

Applicants mustbe authorized towork in the United States without the need for current or future sponsorship.

Pre-Employment Requirements

Employment is contingent upon successful completion of a background check, referencechecksand pre-employment drug screening, wherepermittedby applicable law. For certain roles,additionalscreenings such as a credit check or motor vehicle record review may berequired, where job-related and consistent with business necessity.

Notice to Staffing Agencies and Third-Party Recruiters

Immatics US partners with a select group of approved staffing agencies. Candidate submissions are accepted only from agencies that have a current written agreement with Immatics US and signed and formally engaged by our Talent Acquisition team for an active search. Unsolicited resumes or candidate information, including submissions made directly to hiring managers, will not be considered and are not eligible for placement fees.