CMC Program Manager

Immatics US; Houston (TX); On-site; USD 120,000 - 160,000; Full time

Benefits offered by this job

Health insurance

Dental & Vision

4 weeks vacation annually

Company paid holidays

Life insurance

Short/long-term disability

401(k) with company match

Parental leave

Wellness programs

Job summary

Immatics US is seeking a Program Manager, CMC to lead cross-functional activities across manufacturing, analytical, quality, regulatory, and supply chain in a cell therapy setting. You will drive plans, timelines, risk management and readiness for milestones including regulatory submissions and commercial manufacturing.

The role requires strong communication, vendor coordination and strategic partnering with senior leadership to ensure alignment and on-time execution.

Qualifications

• Minimum 5+ years in biotechnology/pharma clinical development environments.
• Experience in CMC programs across manufacturing, quality, analytical and regulatory operations.
• Cell & gene therapy or immunology experience preferred.

Responsibilities

• Develop and maintain CMC program plans, timelines and risk registers.
• Lead cross-functional CMC meetings and action tracking.
• Coordinate with vendors, CMOs and CDMOs and track deliverables.
• Support strategic governance and senior leadership discussions.

Skills

CMC program management

Cross-functional leadership

Regulatory readiness

Risk management

Stakeholder management

Communication & presentation

Vendors/CDMO coordination

Strategic planning

Education

Bachelor's degree in life sciences/related

Advanced degree (MS/PhD) preferred

Tools

Project management software

Dashboards/reporting tools

Regulatory/tracking systems

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.Why Join Us?Innovative Environment: Help to pioneer advancements in cancer immunotherapy.Collaborative Culture: Be part of a diverse team dedicated to your professional growth.Global Impact: Contribute to therapies that make a lasting impact on patients globally.Role Overview:We are seeking a Program Manager, CMC to lead and coordinate cross-functional Chemistry, Manufacturing, and Controls (CMC) activities within a cell therapy development and manufacturing environment. The Program Manager, CMC will drive planning, execution, and integration across manufacturing, analytical, quality, regulatory, and supply chain functions to support clinical development and commercialization goals. This role serves as a strategic partner across technical and operational teams, ensuring alignment, proactive risk management, and readiness for key milestones, including regulatory submissions and commercial manufacturing.Reports to: Director, Program ManagementLocation: 13203 Murphy Road Suite 100 Stafford, TX 77477Basic Qualifications:Bachelor's degree in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related field5+ years of experience within biotechnology, pharmaceutical, or oncology-focused clinical development environmentsDemonstrated experience in CMC programs and projects working cross-functionally within CMC activities, including manufacturing, quality, analytical, and regulatory operationsAcademic or industry experience in cell and gene therapy, immunology/oncology, or bioprocessing/manufacturing sciencesPreferred Qualifications:Advanced degree such as a Masters or PhD in life sciences, medicine, immunology, oncology, pharmacy, health sciences, or a related fieldExperience supporting late-stage CMC programs in immunology, oncology, or cell and gene therapyProven experience managing programs and critical paths across multiple technical and operational functionsProficiency with project management tools, dashboards, and reporting systems in regulated environmentsProven leadership, stakeholder management, and organizational skills with the ability to manage competing priorities in fast-paced environmentsAn ability to identify risks, drive decision-making, and implement process improvements across cross-functional teamsExperience coordinating external vendors, CMOs, CDMOs, or consulting partnersStrong communication and presentation skills with experience supporting senior leadership discussions and strategic planningIn this role you will:Develop and maintain CMC program plans, timelines, risk registers, trackers, and reporting tools to support integrated program executionManage CMC deliverables, milestones, and critical paths while ensuring alignment with overarching development program timelinesLead and facilitate cross-functional CMC meetings, including agenda development, documentation, action tracking, and follow-up activitiesDrive collaboration across Manufacturing, Process Development, Analytical Development, Quality, Regulatory, Supply Chain, and Patient Operations teamsCoordinate and oversee activities with external vendors, contractors, CMOs, and CDMOsSupport strategic planning, governance, and decision-making activities with department leaders and senior managementContribute to continuous improvement of CMC program management tools, processes, onboarding, and operational best practicesWhat do we offer?At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect if you join ImmaticsComprehensive Benefits:Competitive rates for Health, Dental, and Vision Insurance4 weeks of vacation, granted up front each year and prorated for first and last year of employment.12 company paid holidays7 days of sick time100% employer-paid life insurance up to at 1x annual salary, up to one hundred thousand dollars100% employer-paid short- and long-Term disability coverage401(k) with immediate eligibility and company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.Partially paid parental leave for eligible employees.Additional voluntary employee-paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.Equal Employment OpportunityWe are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, national origin, ancestry, age, marital status, disability, genetic information, veteran status, or any other status protected by applicable law.Reasonable AccommodationsWe are committed to providing reasonable accommodations to individuals with disabilities and to applicants with sincerely held religious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us at [e-mail] AuthorizationApplicants must be authorized to work in the United States without the need for current or future sponsorship.Pre-Employment RequirementsEmployment is contingent upon successful completion of a background check, reference checks and pre-employment drug screening, where permitted by applicable law. For certain roles, additional screenings such as a credit check or motor vehicle record review may be required, where job-related and consistent with business necessity.Notice to Staffing Agencies and Third-Party RecruitersImmatics US partners with a select group of approved staffing agencies. Candidate submissions are accepted only from agencies that have a current written agreement with Immatics US and signed and formally engaged by our Talent Acquisition team for an active search. Unsolicited resumes or candidate information, including submissions made directly to hiring managers, will not be considered and are not eligible for placement fees.