Clinical Trials Site Manager: Operations & Compliance

ECN Operating LLC; Los Angeles (CA); On-site; USD 120,000 - 170,000; Full time

Job summary

ECN Operating LLC is seeking a Site Manager to oversee daily operations of a clinical research site and ensure compliance with GCP and regulatory standards. You will lead study initiation, execution, and close-out, manage budgets, and coordinate staff to deliver high-quality data and patient-centric care.

This role requires strong leadership, excellent communication, and proven experience in managing IRB interactions, vendors, and sponsor relationships in a fast-paced environment in Los Angeles.

Qualifications

• Bachelor's degree in a scientific or healthcare field.
• Minimum of 5 years in clinical research management or other applicable management experience.

Responsibilities

• Manage all aspects of study execution from initiation through close-out to ensure adherence to projected timelines, high-quality protocol execution, and full compliance with internal ECN processes.
• Monitor and manage site-level revenue and expenses, ensuring financial targets are achieved; collaborate with finance and leadership to track study billing, manage budgets, review payment schedules, and control costs.
• Create and implement detailed operational plans tailored to each study, including staffing, equipment, resource needs, and timelines, ensuring effective resource allocation and protocol compliance.
• Ensure regulatory reporting in accordance with GCP, ICH guidelines, and applicable regulations; maintain documentation and audit readiness.
• Oversee data integrity through routine documentation review, source verification, and efficiency checks; ensure accuracy and compliance of all data.
• Maintain accountability for timely data entry and reporting; monitor submission timelines to meet sponsor and regulatory deadlines.
• Meet or exceed participant recruitment and enrollment goals by implementing proactive recruitment strategies and monitoring enrollment performance.
• Serve as primary contact for Sponsors, CROs, and vendors, ensuring timely communication and resolution of operational issues.
• Provide comprehensive training and onboarding for new site staff, ensuring protocol requirements and regulatory guidelines are followed.
• Plan and lead regular site team meetings to foster communication and address operational challenges.

Skills

Communication

Leadership

Project management

Regulatory knowledge

IRB experience

Vendor management

Microsoft Office

RealTime CTMS

GCP

Education

Bachelor's degree in a scientific or healthcare field

Tools

RealTime CTMS

Microsoft Office

Job description

ECN Operating LLC is seeking a Site Manager to oversee daily operations of a clinical research site and ensure compliance with GCP and regulatory standards. You will lead study initiation, execution, and close-out, manage budgets, and coordinate staff to deliver high-quality data and patient-centric care.

This role requires strong leadership, excellent communication, and proven experience in managing IRB interactions, vendors, and sponsor relationships in a fast-paced environment in Los Angeles.