Clinical Trials Manager - Oncology Ops Leader (Hybrid)

Tango Therapeutics

Boston (MA)

Hybrid

USD 120,000 - 180,000

Full time

14 days+

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Job summary

Tango Therapeutics in Boston, MA, is seeking a Clinical Trial Manager (CTM) to lead operational aspects of clinical trials and support the Clinical Trial Leader. The CTM will be a core member of the Clinical Trial Team, serve as primary contact for external partners and vendors, and may lead cross-functional teams on smaller trials or manage aspects of larger studies.

The ideal candidate will have 5+ years in trial management, global development experience, and familiarity with ICH-GCP and

Qualifications

5+ years of trial management experience.
Experience in global clinical development.
Experience in Oncology development (preferred).
Direct experience with health authority inspections (FDA, EMA, MHRA, etc.) incl. sponsor GCP inspections (preferred).
Experience in outsourcing and oversight.
Knowledge of ICH-GCP, FDA guidelines, EU CTR and other relevant guidelines.
Knowledge of financial planning, tracking, and reporting.
Knowledge of trial risk assessment and management.
Familiarity with clinical trial systems (CTMS, eTMF, EDC, IRT, eCOA) and site management metrics, KPIs, and KRIs.
Strong vendor management and project management skills.
Leadership skills with the ability to lead cross-functional teams.
Strong interpersonal and communication skills.
Strong analytical thinking and decision-making capabilities.
Willingness to travel, as required (typically 10–20%).

Responsibilities

Serve as a core member of the Clinical Trial Team and deputy for the CTL during absences.
Organize and coordinate CTT meetings, agendas, minutes, and follow-up actions.
Facilitate communication within the team and with external partners such as CROs and vendors.
Contribute to the development and maintenance of trial-level documents and operational plans, including project management, communication, risk management, and quality plans.
Establish and manage trial-related systems and processes (e.g., central laboratories, eCOA/ ePRO) in alignment with protocol requirements.
Monitor CRO/ vendor performance and ensure timely and accurate data integration, transfer, and reconciliation. Escalate issues to the CTL, as needed
Identify risks and issues and support the development and implementation of mitigation strategies and action plans
Maintain accurate and up-to-date trial information in systems and communication tools
Set up and maintain clinical trial insurance in participating countries
Coordinate with the global supply chain to ensure timely supply and distribution of devices and investigational medicinal products, comparator or co-medication to clinical sites
Prepare and distribute trial-related correspondence and contribute to the development of materials for meetings, newsletters, and websites
Lead logistical arrangements and support content development for external meetings such as investigator meetings and advisory boards
Ensure ongoing inspection and audit readiness. Participate in internal audits and regulatory inspections, as required
Support budget forecasting and accrual processes. Assist with invoice tracking, and processing in line with vendor contracts
Act as CTL when assigned, leading cross-functional CTT to operationalize the protocol of a clinical trial
Lead the development of site management oversight plan and ensure site management oversight including risk management for trials without assigned Site Management Lead (SML)