Clinical Operations Portfolio Project Leader

Enigma Search; South San Francisco (CA); On-site; USD 140,000 - 190,000; Full time

Job summary

Enigma Search is seeking a Sr. Project Manager, Clinical Operations, to drive portfolio-level project management and operational excellence across clinical development programs.

You will partner with Clinical Operations leadership and cross-functional teams to support successful execution across Phase 1–3 studies. The role blends study execution oversight with leadership of strategic initiatives to improve processes, systems, scalability, and organizational effectiveness.

Qualifications

• Bachelor's degree in Life Sciences or related field.
• 6–8+ years of Clinical Project Management experience or 8+ years in Clinical Operations, biotech experience preferred.
• Experience managing complex cross-functional clinical development programs.
• Strong understanding of clinical trial operations across early-stage to Phase 3 studies.
• Ability to lead meetings, manage timelines, mitigate risks, and influence stakeholders without direct authority.

Responsibilities

• Coordinate PM activities across multiple clinical studies, aligning timelines, milestones, risks, dependencies, and deliverables.
• Develop and maintain project plans, dashboards, status reports, risk registers, and KPIs.
• Monitor portfolio progress and facilitate timely issue resolution.
• Support portfolio planning and cross-functional communication.

Skills

Cross-functional leadership

Meetings facilitation

Stakeholder influence

Project management

Communication

Organization

Problem-solving

MS Office

Education

Bachelor's degree in Life Sciences

Tools

CTMS

eTMF

EDC systems

Job description

Enigma Search is seeking a Sr. Project Manager, Clinical Operations, to drive portfolio-level project management and operational excellence across clinical development programs.

You will partner with Clinical Operations leadership and cross-functional teams to support successful execution across Phase 1–3 studies. The role blends study execution oversight with leadership of strategic initiatives to improve processes, systems, scalability, and organizational effectiveness.