Chief Medical Officer

Warman O'Brien; United States; Remote; USD 150,000 - 300,000; Part time

Job summary

Warman O’Brien is partnering with an innovative biotechnology company seeking an experienced Fractional Chief Medical Officer to provide strategic clinical development leadership across a neurodegeneration pipeline, with potential to transition to full-time executive.

This remote US role requires an MD with significant CNS drug development experience, and proven leadership at the CMO/VP level, with a track record in mid-to-late-stage programs and regulatory strategy.

Qualifications

• MD qualification with significant CNS/neuroscience drug development experience.
• Proven leadership in clinical development at senior levels (CMO/SVP/VP).
• Experience in venture-backed or smaller biotech environments is highly desired.
• Ability to operate in a lean, entrepreneurial setting.

Responsibilities

• Lead clinical development strategy across neurodegenerative indications, with a particular focus on dementia-related disorders.
• Provide strategic oversight of clinical programmes, including trial design, regulatory strategy and development planning.
• Work closely with the CEO and executive leadership team to advance key clinical and corporate milestones.
• Support investor discussions, fundraising activities and scientific due diligence.
• Provide medical and scientific leadership, collaborating with external experts, clinical partners and regulatory authorities.
• Contribute to long-term pipeline strategy and future clinical development opportunities.

Skills

MD, CNS drug development

CMO/VP leadership

Education

MD degree

Job description

Fractional Chief Medical Officer – Neurodegeneration

Remote (US)

Warman O’Brien are proud to partner with an innovative biotechnology company seeking an experienced Fractional Chief Medical Officer (CMO) to provide strategic clinical development leadership across their neurodegeneration pipeline, with the potential to transition into a full-time executive role as the company progresses.

Responsibilities:

• Lead clinical development strategy across neurodegenerative indications, with a particular focus on dementia-related disorders
• Provide strategic oversight of clinical programmes, including trial design, regulatory strategy and development planning
• Work closely with the CEO and executive leadership team to advance key clinical and corporate milestones
• Support investor discussions, fundraising activities and scientific due diligence
• Provide medical and scientific leadership, collaborating with external experts, clinical partners and regulatory authorities
• Contribute to long-term pipeline strategy and future clinical development opportunities

Experience required:

• MD qualification with significant experience in CNS / Neuroscience drug development
• Strong clinical development experience in neurodegenerative diseases, ideally Alzheimer's disease or related dementias
• Previous leadership experience as a CMO, SVP or VP of Clinical Development
• Experience working in smaller, clinical-stage biotechnology companies is highly desirable
• Proven experience advancing clinical programmes through mid-to-late-stage development
• Strong understanding of regulatory strategy, clinical data interpretation and the neurodegeneration landscape
• Comfortable operating in a lean, entrepreneurial biotech environment
• Availability to support a fractional engagement, with potential to transition into a full-time position