Chief Medical Officer

Metric Bio; United States; On-site; USD 300,000 - 400,000; Full time

Job summary

A global clinical research organization is seeking a Chief Medical Officer to lead clinical strategy and oversee clinical development programs in Oncology and rare diseases. This pivotal role requires a seasoned physician-scientist with extensive experience in trial design and regulatory submissions. The CMO will collaborate with executive leadership and represent the organization in crucial partnerships and regulatory interactions, shaping the vision and direction of clinical offerings.

Qualifications

• 10+ years in clinical development with complex trial design experience.
• Background in academic oncology research or clinical leadership roles.
• Experience within a CRO, biotech, or high-growth environment.

Responsibilities

• Define and lead the clinical strategy across multiple therapeutic areas.
• Oversee trial designs, clinical protocols, and safety assessments.
• Collaborate with regulatory and operational teams for trial execution.

Skills

Leadership in clinical research

Deep experience in Oncology

Trial design expertise

Strong scientific leadership

Education

MD or MD/PhD

Job description

Metric Bio is partnering with a global clinical research organization to recruit an exceptional Chief Medical Officer. This leader will serve as the organization’s senior‑most medical authority, guiding clinical strategy and overseeing the design and execution of complex clinical development programs across Oncology, CNS, rare diseases, and advanced therapeutic platforms.

Chief Medical Officer (CMO)

The CMO will report directly to the CEO and will be responsible for shaping clinical vision, driving Phase I–IV program excellence, and serving as the organization’s primary clinical representative to biopharmaceutical partners, investigators, regulatory authorities, and key opinion leaders. This is a pivotal executive role for a seasoned physician‑scientist with deep clinical research experience, strong scientific leadership capabilities, and an entrepreneurial mindset.

Key Responsibilities

• Define and lead the organization’s clinical strategy across Oncology, CNS, and novel therapeutic modalities including biologics, ADCs, and innovative small molecules.
• Serve as the principal medical authority for all clinical programs from early development through late‑stage trials.
• Partner with the CEO and executive leadership to develop long‑term clinical and corporate strategy.
• Oversee the evolution of clinical offerings and support business growth initiatives.

• Provide medical oversight for all trial designs, clinical protocols, safety assessments, and data interpretation.
• Ensure scientific rigor and excellence in clinical deliverables such as protocols, clinical study reports, and safety narratives.
• Collaborate with biostatistics, regulatory, and operational teams to ensure high‑quality, regulatory‑compliant clinical trial execution.
• Contribute to major regulatory submissions (IND, CTA, NDA) and represent the company in regulatory interactions as needed.

• Act as the senior clinical representative during sponsor meetings, pre‑award discussions, bid defences, and strategic planning sessions.
• Cultivate strong relationships with biopharma executives, investigators, academic partners, and global KOLs.
• Represent the organization at industry conferences, scientific forums, and external events.

• Communicate clinical vision, program updates, and risk mitigation strategies across all levels of the organization.
• Collaborate closely with medical writing and scientific teams to ensure quality, accuracy, and consistency of clinical documents.
• Foster a culture of transparency, scientific excellence, and high collaboration.
• Recruit, lead, and mentor clinical and scientific staff, promoting continuous professional growth.
• Build a high‑performing clinical organization with strong capabilities across therapeutic areas.
• Represent the company as a speaker, panellist, and subject‑matter expert at external meetings.

Qualifications

• MD or MD/PhD with substantial clinical research and drug development leadership experience.
• 10+ years in clinical development with deep experience in early‑phase and complex trial design, preferably in Oncology, CNS, or rare diseases.
• Hands‑on experience with biologics, ADCs, and innovative small‑molecule platforms.
• Background in academic oncology research or clinical leadership roles in biotech strongly preferred.
• Experience working within a CRO, biotech, or high‑growth clinical environment.

Contact

To learn more about this role, please contact Oli Oldham at [e-mail].