Chemist II

Katalyst CRO; Worcester (MA); On-site; USD 65,000 - 95,000; Full time

Job summary

An innovative firm is seeking a skilled analytical scientist to conduct mass spectrometry analyses and perform assessments of biologics and biotherapeutics. In this dynamic role, you will leverage your expertise in chromatography and electrophoresis techniques to ensure optimal laboratory functioning. Collaborate closely with a multidisciplinary team, contribute to discussions, and present findings to stakeholders. This position offers an exciting opportunity to thrive in a fast-paced environment while driving innovation and improving processes. If you are passionate about advancing scientific knowledge and making a meaningful impact, this role is perfect for you.

Qualifications

• 3+ years of experience in mass spectrometry and chromatography techniques.
• Hands-on expertise with mass spectrometry platforms and workflows.

Responsibilities

• Conduct mass spectrometry analyses for biologics and biotherapeutics.
• Perform analytical assessments using SEC, RPLC, and CE techniques.

Skills

Mass Spectrometry

Size Exclusion Chromatography (SEC)

Reverse Phase Liquid Chromatography (RPLC)

Capillary Electrophoresis (CE)

Analytical Proficiency

Dynamic Light Scattering (DLS)

Differential Scanning Fluorimetry (DSF)

Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

X-ray Crystallography

Communication Skills

Education

Bachelor's Degree in Chemistry/Biochemistry

Master's Degree in Chemistry/Biochemistry

Tools

Orbitrap

Q-ToF

MS Software

Electronic Laboratory Notebooks (ELN)

Job description

Responsibilities

• Conduct mass spectrometry analyses for comprehensive characterization of biologics and biotherapeutics, including intact, reduced, subunit, and peptide mapping approaches.
• Perform regular analytical assessments of biologics utilizing methods such as Size Exclusion Chromatography (SEC), Reverse Phase Liquid Chromatography (RPLC), Capillary Electrophoresis (CE), and automation technologies.
• Ensure the optimal functioning of laboratory equipment through routine maintenance and effective troubleshooting of experimental challenges.
• Evaluate, document, and succinctly report experimental data, formulate well-supported conclusions, and design subsequent experiments informed by multidisciplinary insights.
• Document laboratory activities in Electronic Laboratory Notebooks (ELN) in accordance with best practices for good documentation.
• Work closely with other scientists and departments to ensure alignment and progress on project goals.
• Contribute to team discussions, share valuable insights, and present experimental findings and progress updates to colleagues and stakeholders.
  
  

Requirements:

• Bachelor's or Master's degree in Chemistry/Biochemistry with over 3 years of relevant experience.
• Demonstrated hands-on expertise with various mass spectrometry platforms, including Orbitrap and Q-ToF, along with proficiency in MS workflows for protein characterization and the use of MS software for analyzing both routine and complex datasets.
• Solid analytical proficiency in a range of chromatographic and capillary electrophoresis techniques.
• Familiarity with biophysical and structural methods, such as Dynamic Light Scattering (DLS), Differential Scanning Fluorimetry (DSF), Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS), and X-ray crystallography, is a plus.
• Experience in working with biologics, monoclonal antibodies, and/or protein therapeutics is a plus.
• Goal-oriented team player with exceptional verbal and written communication skills, a strong positive attitude, and the ability to thrive in a fast-paced, multidisciplinary environment.
• Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
• Learns fast, grasps the "essence and can change course quickly when indicated. Raises the bar and is never satisfied with the status quo.
• Creates a learning environment, open to suggestions and experimentation for improvement.
• Embraces the ideas of others, nurtures innovation and manages innovation to reality.