Cardiac Organoid Research Scientist II

BioSpace; Frederick (MD); On-site; USD 72,000 - 103,000; Full time

Job summary

Leidos Biomedical Research’s Frederick National Laboratory for Cancer Research seeks a Research Associate II for the Cardiac Tissue Engineering Laboratory. You will advance human iPSC-derived cardiac organoids, optimize culture protocols, and perform detailed phenotypic characterizations using immunofluorescence, microscopy, flow cytometry, and qPCR.

You will develop SOPs, support QC workflows, and train junior staff while collaborating with a multidisciplinary team to standardize organoid

Qualifications

• Bachelor’s degree or 4 years relevant experience.
• Minimum 5 years of cardiac organoid biology or related experience.
• Proficiency with Microsoft Office.
• Ability to obtain and maintain a security clearance.

Responsibilities

• Independently perform and troubleshoot complex procedures involving human iPSC maintenance, differentiation, and generation of 3D cardiac organoids.
• Develop, optimize, and validate organoid culture protocols, differentiation procedures, and assays.
• Maintain and evaluate the quality of human pluripotent stem cell cultures.
• Perform advanced cellular, molecular, and functional characterization of cardiac organoids (immunofluorescence, microscopy, qPCR, flow cytometry).
• Implement and optimize functional assays to evaluate cardiac organoid function.
• Develop and maintain SOPs, documentation, and workflows for consistent production and characterization.
• Provide training to junior staff and support standardized culture procedures.
• Collaborate across the SOM Initiative to standardize methodologies and data integration.
• Contribute to scientific reports and publications.

Skills

Microsoft Office

Security clearance

Cardiac organoid biology

iPSC culture

Calcium imaging

Confocal microscopy

Flow cytometry

qPCR

Immunofluorescence

Education

Bachelor’s degree or 4 years relevant experience

BSc or MSc in Cell Biology / Biomedical Engineering / related

Tools

Confocal microscopy

qPCR

Flow cytometry

Job description

Leidos Biomedical Research’s Frederick National Laboratory for Cancer Research seeks a Research Associate II for the Cardiac Tissue Engineering Laboratory. You will advance human iPSC-derived cardiac organoids, optimize culture protocols, and perform detailed phenotypic characterizations using immunofluorescence, microscopy, flow cytometry, and qPCR.

You will develop SOPs, support QC workflows, and train junior staff while collaborating with a multidisciplinary team to standardize organoid