Bispecific Antibody Architect — Lead AI-Driven Design

Regeneron Pharmaceuticals, Inc.; Tarrytown (GA); On-site; USD 151,000 - 246,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Senior Principal Scientist to lead a small team in the Bispecific Antibodies group, guiding structure-guided design and integration of AI/ML-enabled approaches from concept to IND.

You will oversee high-throughput engineering, mentor scientists, and partner with biology and computational groups to advance next-generation multispecific therapeutics, applying structural biology to solve complex engineering challenges.

Qualifications

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field.
• 8+ years of post-Ph.D. experience, including at least 5 years in biotech/pharmaceutical industry.
• At least 2 years of direct people management experience with a track record of developing scientists.
• Experience engineering bispecific or multispecific antibody formats with hands-on cloning, expression, purification, and characterization.

Responsibilities

• Set molecular design strategy for bispecifics based on biology, structure, and mechanism.
• Lead structure-guided design of novel formats and optimize binding-arm selection and geometry.
• Drive engineering campaigns integrating AI/ML and in silico design into design-build-test-learn cycles.
• Oversee high-throughput construct generation, expression, purification, biophysical characterization, and cell-based assays.
• Build datasets and design rules to strengthen the bispecific platform across diseases.
• Lead, mentor, and develop a team of scientists, partnering with internal and external groups.

Education

Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field

Tools

AlphaFold

Rosetta

MOE

PyMOL

Job description

Regeneron Pharmaceuticals, Inc. seeks a Senior Principal Scientist to lead a small team in the Bispecific Antibodies group, guiding structure-guided design and integration of AI/ML-enabled approaches from concept to IND.

You will oversee high-throughput engineering, mentor scientists, and partner with biology and computational groups to advance next-generation multispecific therapeutics, applying structural biology to solve complex engineering challenges.