Senior Principal Scientist, Bispecifics & Antibody Engineering

Regeneron Pharmaceuticals, Inc.; Tarrytown (GA); On-site; USD 151,000 - 246,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. seeks a Senior Principal Scientist to lead a small team in the Bispecific Antibodies group, guiding structure-guided design and integration of AI/ML-enabled approaches from concept to IND.

You will oversee high-throughput engineering, mentor scientists, and partner with biology and computational groups to advance next-generation multispecific therapeutics, applying structural biology to solve complex engineering challenges.

Qualifications

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field.
• 8+ years of post-Ph.D. experience, including at least 5 years in biotech/pharmaceutical industry.
• At least 2 years of direct people management experience with a track record of developing scientists.
• Experience engineering bispecific or multispecific antibody formats with hands-on cloning, expression, purification, and characterization.

Responsibilities

• Set molecular design strategy for bispecifics based on biology, structure, and mechanism.
• Lead structure-guided design of novel formats and optimize binding-arm selection and geometry.
• Drive engineering campaigns integrating AI/ML and in silico design into design-build-test-learn cycles.
• Oversee high-throughput construct generation, expression, purification, biophysical characterization, and cell-based assays.
• Build datasets and design rules to strengthen the bispecific platform across diseases.
• Lead, mentor, and develop a team of scientists, partnering with internal and external groups.

Education

Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field

Tools

AlphaFold

Rosetta

MOE

PyMOL

Job description

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Principal Scientist to lead a small team within our Bispecific Antibodies group, using structural insight to design, engineer, and optimize next-generation bispecific and multispecific antibody therapeutics. In this role, you will integrate structural data with AI/ML-enabled design and high-throughput, automated experimental validation, co-championing programs with biology leads from concept to IND. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

• Location: Tarrytown, NY
• Work model/flexibility: Onsite

Discover your role:

• Set molecular design strategy for bispecific and multispecific antibodies based on target biology, structure, and mechanism of action
• Lead structure-guided design of novel formats, including binding-arm selection, epitope and geometry optimization, and chain pairing, using tools such as AlphaFold, Rosetta, MOE, and PyMOL
• Drive protein engineering campaigns that integrate AI/ML and in silico design into iterative design-build-test-learn cycles with computational partners
• Oversee high-throughput construct generation, expression, purification, biophysical characterization, and cell-based functional assays to rank molecules on activity and developability
• Build curated engineering datasets and design rules that strengthen the bispecific platform across oncology, immunology, and infectious disease
• Lead, mentor, and develop a team of scientists, partnering with internal and external groups to advance the pipeline
• Apply structural biology to solve hard antibody and protein engineering problems, combining experimental data with computational and AI/ML-driven design
• Lead multiple projects in parallel with strong organization and flexibility, communicating structural insights clearly to non-specialist audiences

This role requires:

• Ph.D. in Structural Biology, Biochemistry, Biophysics, Protein Engineering, Computational Biology, Immunology, or a related field
• 8+ years of post-Ph.D. experience, including at least 5 years in the biotech/pharmaceutical industry
• At least 2 years of direct people management experience with a record of success developing scientists
• A record of innovation and research accomplishments in antibody or protein therapeutic engineering (publications, patents, or programs advanced into development)
• Experience engineering bispecific or multispecific antibody formats, with deep hands‑on expertise in molecular cloning, protein expression, purification, and biochemical/biophysical characterization
• Experience with mammalian cell culture and cell-based assay development
• Preferred: experience applying computational design and AI/ML tools to protein engineering, and with automated or high‑throughput protein engineering workflows

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on-site. Please speak with your recruiter and hiring manager for more information about on-site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$150,500.00 - $245,500.00