Biomarker Program Lead – Clinical Trials

Treeline Biosciences; Watertown (MA); On-site; USD 187,200 - 200,000; Full time

Job summary

Treeline Biosciences is seeking a Biomarker Lead to plan and execute biomarker strategies across one to two clinical programs, from design through data integration. The role centers on coordinating biomarker plans, selecting bioassay labs/CROs, and managing assay transfer and validation to ensure timely, high-quality data for decision-making.

You will collaborate across Translational Biology, Clinical Development, Data Management, Biostatistics, and Regulatory teams, driving data quality and

Qualifications

• PhD with postdoctoral training in Life Sciences or related field.
• 4–5 years of industry experience in clinical biomarkers or translational medicine.
• Proven expertise in assay transfer, validation and CRO/lab oversight.

Responsibilities

• Develop and oversee biomarker plans for each clinical protocol.
• Identify and qualify bioassay labs/CROs for biomarker assays.
• Lead assay transfer from Translation biology teams to labs/CROs, ensuring validation.
• Oversee testing at bioassay labs/CROs, ensuring quality and protocol adherence.
• Collaborate with Clinical Development, Data Management, Biostatistics, and Regulatory to align deliverables with program needs.
• Provide updates on biomarkers to internal stakeholders.
• Analyze biomarker data with Translational Biology and Clinical Development colleagues to test program hypotheses.

Skills

Cross-functional leadership

Communication

Organizational skills

Data analysis

Education

PhD in Life Sciences

Tools

Flow cytometry

IHC

NGS

Proteomics

Bioassay validation

Job description

Treeline Biosciences is seeking a Biomarker Lead to plan and execute biomarker strategies across one to two clinical programs, from design through data integration. The role centers on coordinating biomarker plans, selecting bioassay labs/CROs, and managing assay transfer and validation to ensure timely, high-quality data for decision-making.

You will collaborate across Translational Biology, Clinical Development, Data Management, Biostatistics, and Regulatory teams, driving data quality and