Bio Bioassay Researcher Candidate Comparison Matrix

Guidehouse Inc.; Silver Spring (MD); In loco; USD 98.000 - 163.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical insurance

Parental Leave

401(k) Plan

Paid holidays

Descrizione del lavoro

Guidehouse is seeking a scientific professional to culture and maintain immortalized cell lines under air-liquid interface conditions, and to optimize transcytosis and permeation bioassays evaluating antibody transport across polarized epithelial layers.

You will validate bioassays, perform qRT-PCR, ELISA, Western blotting, and immunohistochemistry, and document data in electronic notebooks for FDA-related research.

Competenze

• Bachelor's degree in a relevant field is required.
• Minimum four years of hands-on laboratory experience in cell-based assay development.
• Experience with mammalian cell culture and in vitro model systems.
• Experience with qRT-PCR, ELISA, western blotting, or immunohistochemistry.
• Ability to design, optimize, validate bioassays against defined criteria.
• Strong documentation, data analysis, writing, and communication skills.

Mansioni

• Culture and maintain immortalized cell lines under air-liquid interface conditions.
• Optimize transcytosis and permeation bioassays for antibody transport across epithelial layers.
• Validate bioassays for reproducibility, sensitivity, and specificity.
• Perform hands-on lab work including qRT-PCR, ELISA, western blotting, IHC.
• Collect and document laboratory data in accordance with FDA standards.
• Maintain electronic notebooks with rolling documentation.
• Contribute to scientific summaries, reports, and presentations.

Conoscenze

Cell culture

qRT-PCR

ELISA

Western blot

Immunohistochemistry

Data analysis

Scientific writing

Documentation

Formazione

Bachelor's degree

Strumenti

qRT-PCR instrument

ELISA reader

Descrizione del lavoro

Job Family : Scientific Research & Analysis

Travel Required : None

Clearance Required : None

What You Will Do :

• Culture and maintain identified immortalized cell lines under air-liquid interface conditions.
• Optimize transcytosis and permeation bioassays to evaluate apical-to-basal and basal-to-apical transport of monoclonal antibodies and other biological therapeutics across polarized epithelial cell layers.
• Validate bioassays for reproducibility, sensitivity, and specificity.
• Perform hands-on laboratory work using cell culture, qRT-PCR, ELISA, western blotting, immunohistochemistry, and other relevant in vitro and analytical techniques.
• Collect, process, analyze, and document laboratory data accurately and completely in accordance with FDA laboratory standards.
• Maintain electronic laboratory notebooks and experimental records on a rolling basis with no documentation gaps.
• Contribute to collaborative research activities, data analysis, scientific summaries, technical reports, presentations, and other written materials.
• Participate in interdisciplinary teams, scientific discussions, weekly research updates, ad hoc meetings, and knowledge-transfer activities.
• Immediately report safety incidents, near-misses, potential hazards, anomalous results, risks, issues, and concerns through the required FDA channels.
• Protect all government research information and data from unauthorized release.

What You Will Need :

• Bachelor's Degree Required
• Minimum of four (4) years of hands-on laboratory experience in cell-based assay development and biological therapeutics research.
• Experience with mammalian cell culture and in vitro model systems.
• Experience with one or more relevant techniques, including qRT-PCR, ELISA, western blotting, immunohistochemistry, or comparable biochemical assays.
• Experience designing, optimizing, characterizing, and validating bioassays against defined performance criteria.
• Ability to produce scientifically sound, reproducible, and thoroughly documented experimental work and data.
• Strong laboratory documentation, data analysis, scientific writing, presentation, and technical communication skills.
• Ability to work onsite at the White Oak FDA Campus and comply with FDA facility access, safety, security, badging, and laboratory requirements.
• Ability to obtain a favorable Tier 1 background determination and PIV card. The solicitation does not specify a minimum degree or minimum years of experience.

What Would Be Nice To Have :

• Experience developing transcytosis or permeation assays using polarized epithelial cell layers and air-liquid interface conditions.
• Experience evaluating monoclonal antibodies, inhaled or intranasally delivered biological therapeutics, or other complex biological products.
• Familiarity with FDA or OPQR laboratory standards, SOPs, pharmaceutical quality research, or regulatory science.
• Experience collaborating with internal and external research partners and sharing laboratory methods and protocols.
• Experience preparing weekly research updates and final research summaries in Microsoft Word or PowerPoint.

The annual salary range for this position is $98,000.00-$163,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

• Medical, Rx, Dental & Vision Insurance
• Personal and Family Sick Time & Company Paid Holidays
• Parental Leave
• 401(k) Retirement Plan
• Group Term Life and Travel Assistance
• Voluntary Life and AD&D Insurance
• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
• Transit and Parking Commuter Benefits
• Short-Term & Long-Term Disability
• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
• Employee Referral Program
• Corporate Sponsored Events & Community Outreach
• Care.com annual membership
• Employee Assistance Program
• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer-Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualif