Bio-Analytical Co-op-Northeastern Students

Socket.dev; Boston (MA); On-site; USD 36,000 - 48,000; Part time

Job summary

Seaport Therapeutics seeks a bioanalysis co-op to join the Discovery team in a lab-based role focused on LC-MS for drug screening. The position offers exposure to preclinical workflows within a startup environment and contributes to advancing candidates from our Glyph prodrug platform.

Ideal candidates are pursuing a Master’s degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or related fields, with prior lab/co-op experience and a solid foundation in LC-MS, HPLC,

Qualifications

• Enrolled in a Master’s level program in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or related field.
• Previous Co-op or lab experience preferred.
• Knowledge of HPLC, reverse phase chromatography, mass spectrometry instrumentation, enzyme kinetics, protein precipitation, liquid-liquid extraction.
• Strong organizational skills, attention to detail, and eagerness to learn.

Responsibilities

• Executing in vitro experiments, using LC-MS, for the screening of lipid prodrugs to support preclinical discovery
• Processing and analyzing in vivo samples (plasma, lymph fluid, etc.) to generate DMPK data for various prodrugs
• Contributing to the development and optimization of LC-MS methods for both quantitative and qualitative analysis
• Routine use and troubleshooting of LC-MS instrumentation
• Documenting all experiments using an electronic notebook and analyzing data for reports and regular internal presentations

Skills

LC-MS

HPLC

Mass spectrometry

Enzyme kinetics

Protein precipitation

Liquid-liquid extraction

Education

Master's student in Chemistry/Biochemistry/Pharmaceutical Sciences/Chemical Engineering

Tools

LC-MS instrumentation

Job description

Seaport Therapeutics is a clinical-stage therapeutics company advancing the development of novel neuropsychiatric medicines in areas of high unmet patient needs. The Company has a proven strategy of advancing clinically validated mechanisms previously held back by limitations that are overcome with its proprietary GlyphTMtechnology platform. All the therapeutic candidates in its pipeline of first and best-in-class medicines are based on the Glyph platform, which is uniquely designed to enable oral bioavailability, bypass first-pass metabolism and reduce hepatotoxicity and other side effects. Seaport is led by an experienced team that invented and advanced important neuropsychiatric medicines and are guided by an extensive network of renowned scientists, clinicians and key opinion leaders. For more information, please visitwww.seaporttx.com.

Job Description

Seaport Therapeutics is seeking a co-op student for a lab-based bioanalysis position to be part of our Discovery team. This co-op will have a focus on LC-MS to assist in the screening of novel drugs. We are looking for a highly motivated individual who is looking to be a part of a multidisciplinary team and to gain experience in a startup environment. This position will contribute to advancing the pipeline of impactful candidates generated from our novel Glyph™ prodrug platform.

Some of the responsibilities will include:

• Executing in vitro experiments, using LC-MS, for the screening of lipid prodrugs to support preclinical discovery
• Processing and analyzing in vivo samples (plasma, lymph fluid, etc.) to generate DMPK data for various prodrugs
• Contributing to the development and optimization of LC-MS methods for both quantitative and qualitative analysis
• Routine use and troubleshooting of LC-MS instrumentation
• Documenting all experiments using an electronic notebook and analyzing data for reports and regular internal presentations

Experience and Skills

• Enrolled in a Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or related program at the Master's Level
• Previous Co-op or lab experience is preferred
• Knowledge of or experience with: HPLC, reverse phase chromatography, mass spectrometry instrumentation, enzyme kinetics, protein precipitation, liquid-liquid extraction
• Strong organizational skills, attention to detail, and eagerness to learn.