Associate Scientist, Technical Operations New Fremont, CA

Personalis, Inc.; Fremont (CA); Hybrid; USD 109,000 - 132,000; Full time

Benefits offered by this job

Annual bonus

Equity (long-term incentive)

Medical benefits

Dental benefits

Vision benefits

401(k) match

ESPP

Job summary

Personalis, Inc. in Fremont, CA is seeking an Associate Scientist to initiate and support improvements to Next Generation Sequencing (NGS) products and to lead transfer and validation into operations.

The role requires hands-on molecular biology skills and familiarity with high-throughput LIMS and robotic systems. You will collaborate with R&D, Operations, Quality, and Regulatory teams to implement new products, validate workflows, and ensure scalable processes in a CLIA/CAP-regulated

Qualifications

• Bachelor’s degree in a life sciences field required, advanced degree a plus.
• Hands-on experience with molecular biology techniques.
• Familiarity with high-throughput lab information systems (LIMS) and robotic liquid handlers.
• Excellent verbal and written communication skills are required.
• Six Sigma Green Belt is a plus; tbd on project-based contributions.

Responsibilities

• Partner with R&D, Operations, LIMS, Supply Chain, Data Analytics, Quality, and Regulatory to implement new products and automate processes.
• Plan operational releases and manage product life cycle.
• Contribute to scalable lab operational processes and meet regulatory requirements.
• Support non-conformance investigations and corrective actions.
• Assist the LIMS team with deploying improvements to Operations Informatics systems.

Skills

Molecular biology techniques

LIMS / informatics experience

Robotic liquid handling

Communication skills

Analytical thinking

Six Sigma Green Belt (bonus)

Education

Bachelor’s degree in Biology, Chemistry, Molecular Biology, Chemical Engineering or related field

Advanced degree (advantageous)

Tools

LIMS integration

Laboratory automation experience

Job description

Associate Scientist, Technical Operations

Fremont, CA

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

As an Associate Scientist within the Technical Operations group, you will be responsible for initiating, supporting, and implementing improvements to existing Next Generation Sequencing (NGS) based products and leading transfer and validation of new processes and products into operations. The ideal candidate will have hands‑on experience with molecular biology techniques and familiarity working with high throughput lab information systems and robotic liquid handlers. You will be encouraged to think outside the box and creatively solve problems while collaborating with different groups across the organization.

Responsibilities:

Partner with cross‑functional teams such as R&D, Operations, LIMS, Supply Chain, Data Analytics, Quality, and Regulatory to implement new products and automated processes, plan operational releases, and manage product life cycle.

Contribute to the company’s strategic plan to ensure the sustainability and scalability of lab operational processes and to meet evolving regulatory requirements.

Participate in lab operations troubleshooting effort and support non‑conformance investigations and corrective action implementations.

Assist the LIMS team with deploying improvements and extensions to the existing Operations Informatics systems, as well as associated lab instruments and software systems.

Plan and drive execution of end‑to‑end testing and validation pertaining to Next Generation Sequencing assays and workflows.

Partner with lab operations, product development, research and automation teams to identify areas of growth in sample volume and implement potential operational improvements.

Participate in project core teams, lead working teams, and collaborate cross‑functional to formulate relevant project deliverables per the company’s product development process.

Qualifications:

A Bachelor’s degree in Biology, Chemistry, Molecular Biology, Chemical Engineering or related field with a minimum of 6 years relevant experience. An advanced degree can be advantageous. CLS certification is highly desirable.

Excellent verbal and written communication skills and willingness to collaborate cross‑functionally.

Practical hands‑on knowledge of Next Generation Sequencing technologies and sample preparation workflows performed in CLIA/CAP regulated environment. Experience with ISO 13485/FDA is a plus.

LIMS integration and Laboratory automation experience.

Proven ability to think innovatively toward solving problems effectively and efficiently. Six Sigma Green Belt certification is a plus.

Analytical, detail‑oriented, organized, takes initiative, and self‑motivated.

The hiring range for this position is $109,000 to $132,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s geographic region, job‑related knowledge, skills, and experience among other factors. Our full‑time regular positions also include an annual performance‑based bonus (or a sales incentive plan) and long‑term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical,dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self‑identification survey.Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiringprocess or thereafter. Any information that you do provide will be recorded and maintained in aconfidential file.

As set forth in Personalis, Inc’s Equal Employment Opportunity policy,we do not discriminate on the basis of any protected group status under any applicable law.

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection.As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measurethe effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categoriesis as follows:

A \"disabled veteran\" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service‑connected disability.

A \"recently separated veteran\" means any veteran during the three‑year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An \"active duty wartime or campaign badge veteran\" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An \"Armed forces service medal veteran\" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Voluntary Self-Identification of Disability

Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 07/31/2029

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp .

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

• Alcohol or other substance use disorder (not currently using drugs illegally)


• Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS


• Blind or low vision


• Cancer (past or present)


• Cardiovascular or heart disease


• Celiac disease


• Cerebral palsy


• Deaf or serious difficulty hearing


• Diabetes


• Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders


• Epilepsy or other seizure disorder


• Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome


• Intellectual or developmental disability


• Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD


• Missing limbs or partially missing limbs


• Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports


• Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)


• Neurodivergence, for example, attention‑deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities


• Partial or complete paralysis (any cause)


• Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema


• Short stature (dwarfism)


• Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.