Associate Scientist, Protein Science

Soufflé Therapeutics; Watertown (MA); Sur place; USD 70 000 - 90 000; Plein temps

Résumé du poste

Soufflé Therapeutics is seeking an Associate Scientist to join the Protein Production team within Protein Science. You will produce antibodies and antibody-like proteins from mammalian cells to support in vitro and in vivo studies, directly impacting program timelines.

This hands-on role involves maintaining AKTA systems, cell culture, protein purification, data analysis, and presenting results at group meetings.

Qualifications

• Experience with aseptic mammalian cell culture and transfection.
• Proficient in protein purification and chromatography.
• Strong data analysis and meticulous documentation.
• Able to work in a fast-paced, collaborative environment.

Responsabilités

• Produce antibodies and antibody-like proteins from mammalian cells.
• Maintain AKTA and other protein production instrumentation.
• Maintain cell cultures and perform purification.
• Analyze data and present findings at group meetings.
• Collaborate with cross-functional teams to advance projects.

Connaissances

Cell culture

Aseptic technique

Protein purification

SDS-PAGE

Western blot

Data analysis

Documentation

Transient transfection

Formation

BS or MS in relevant life sciences

Outils

AKTA systems

SDS-PAGE equipment

Chromatography

UV spectrophotometry

Description du poste

Soufflé Therapeutics is a biotech company focusing on the cell-type specific delivery of genetic medicines. It's team of driven scientists is making a mark in delivery of oligonucleotides to extrahepatic tissues. We thrive in a purpose-building lab and office space in Watertown. Come and join us in our quest!

Position Summary:

Soufflé Therapeutics is growing its Protein Production team within Protein Science to increase throughput and capabilities and to build the redundancy that keeps work flowing for our project teams. As an Associate Scientist, you will produce antibodies and antibody-like proteins from mammalian cells to support our in vitro and in vivo studies. This is a new, hands-on role with direct impact on how quickly our programs move.

Key Responsibilities

• Produce different ligand formats, including antibodies and antibody-like proteins, from mammalian cells to support in vitro and in vivo studies


• Maintain AKTA and other protein production instrumentation


• Maintain cells in culture for protein production


• Analyze and present data at group meetings


• Represent the protein production team at cross-functional meetings

What Success Looks Like

• In 3 months: Maintain cell cultures, purify your first proteins, and become acquainted with our instrumentation and ELN environment


• In 6 months: Use instrumentation independently, understand the production workflow, and be proficient in the ELN environment


• In 12 months: Deliver batches of proteins to project teams, understand Soufflé priorities, and present at group meetings

Qualifications — Required

• 1 to 2 years of relevant experience with an MS, or 2 to 3 years with a BS


• Experience with cell culture using aseptic technique, transient transfection, protein purification and chromatography, SDS-PAGE, Western blot, and UV absorbance


• Team-oriented and detail-oriented, with strong documentation, record keeping, and data analysis skills


• Eager to learn new things and comfortable working in a fast-paced environment

Qualifications — Preferred

• Protein analytics experience: ELISA, BLI/SPR, HPLC, and thermal shift assays


• Microbiology experience: bacterial cell culture


• Molecular biology experience: plasmid design and propagation

Education

• BS or MS in a relevant scientific discipline

At Soufflé Therapeutics, we are intentional about building an equitable culture. How we treat our people is reflective of this focus. We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

This is an onsite position in Watertown, MA (US) with flexibility as needed for collaboration and external engagements.