Associate Scientist – Protein Characterization

Virtual Company; North Chicago (IL); Presencial; USD 69.000 - 76.000; Tempo integral

Resumo da vaga

The Fountain Group seeks a Biologics Developability professional to support developability efforts for our biologics pipeline. The role involves screening candidates, performing conformational stability, viscosity measurements, and stability assessments across various solution conditions.

You will collaborate with Discovery, Analytical, and Process Development teams in a fully onsite North Chicago, IL setting, with relocation after offer completion and a 1-year contract to start with potential

Qualificações

• Bachelor's degree with 2-4 years of experience; master's degree with 1-2 years of relevant lab experience; PhDs are considered overqualified.
• Strong background with biologics / large molecule formulation.
• Hands-on experience working with proteins, preferably antibodies.

Responsabilidades

• Execute characterization studies including DSF/DSC and viscosity assessments.
• Evaluate stability under varying solution conditions and stresses from manufacturing processes.
• Communicate findings and risks through presentations and technical reports to cross-functional teams.

Conhecimentos

Biologics formulation

Protein characterization

Stability testing

HPLC/UPLC operation

Formação

Bachelor's degree

Master's degree

Ferramentas

HPLC/UPLC

SEC

capillary electrophoresis

icIEF

particle analysis

DLS

DSF

DSC

UV-Vis

Descrição da vaga

Details for the positionare as follows:

• Location: North Chicago, 60064 - open to candidates willing to relocate at there own expense 2-4 weeks after an offer.
• Fully onsite, Monday-Friday, 40 hours/week.
• Rate: $50-55 an hour
• 1 year contract to start with the possibility of extension or conversion depending on performance and business needs

Job Description:

• The Biologics CMC Developability (BCD) group sits at the interface of discovery and development. The core role of BCD is to generate developability insights that inform candidate selection, molecular optimization, and advancement decisions across Client's biologics pipeline. Developability assessments focus on identifying manufacturability, formulation, stability, and product quality risks early in development to enable selection of robust drug candidates. Our team works across a wide range of therapeutic areas and diverse classes of biologics therapeutics, including monoclonal antibodies, bispecific and multispecific antibodies, antibody drug conjugates (Client), fusion proteins, and emerging biologic modalities.
• We are looking for a highly motivated person to support these developability efforts and early-stage assessment of candidates to move Client’s ever-evolving pipeline forward. In this role, the candidate will be part of a global team and will work closely with scientists from multiple functional areas, including Discovery, Analytical, and Process R&D.
• Support candidate screening activities by executing characterization studies including conformational stability assessment via differential scanning fluorimetry/calorimetry experiments, solution viscosity determination, and other techniques
• Evaluate drug candidate chemical and physical stability against different solution conditions (pH, ionic strength, temperature, light, etc.) and physical stresses arising from manufacturing process conditions (freeze thaw, mixing, filtration, filling, and lyophilization)
• Communicate scientific findings and development risks through clear presentations and technical reports to cross-functional teams and senior stakeholders
• Stay current with the literature and support new scientific initiatives

Required Skills:

• Bachelor's degree with 2-4 years of experience master's degree with 1-2 years of relent lab experience. PhDs are considered as overqualified.
• Strong background with biologics / large molecule formulation
• Must have hands-on experience working with proteins in some capacity, preferably antibodies.
• HPLC or UPLC experience REQUIRED
• Strong laboratory skills focused on chemical and structural characterization of biologics (HPLC/UPLC, SEC, capillary electrophoresis, icIEF, particle analysis, DLS, DSF, DSC, UV-Vis, and related developability assessment techniques)
• Experience performing chemical and physical stability against different solution conditions
• Candidates that are relocating must be able to do so 2-4 weeks after an offer and have a valid US work authorization before starting.