Associate Scientist — In Vitro Immunology & Flow Cytometry

Takeda; Boston (MA); On-site; USD 104,000 - 163,000; Full time

Job summary

Takeda seeks an Associate Scientist to advance GIDDU programs through in vitro pharmacology and assay development. You will design, execute, interpret, and document studies using primary human immune cells to generate high-quality data aiding program decisions and development activities.

You will lead multi-parameter flow cytometry assay qualification and analysis, while collaborating with cross-functional teams to address challenges and ensure robust scientific progress.

Qualifications

• Bachelor’s degree with 8+ years of relevant experience or Master’s with 4+ years.
• Hands-on experience designing and executing in vitro assays using primary human immune cells.
• Experience executing and analyzing multi-parameter flow cytometry assays, including panel design, staining, acquisition, compensation, gating, troubleshooting, and analysis.
• Experience generating reproducible pharmacology data and clearly documenting experimental results.
• Strong scientific writing skills, including preparation of study summaries, technical reports, figures, and presentations.
• Experience supporting development-stage studies or pharmacology data packages; experience with antibody-based therapeutics, CD38 biology, B cell or plasma cell biology, or immune-mediated disease pharmacology is preferred.
• Experience with target engagement, receptor occupancy, immune cell depletion, cytokine, proliferation, or viability assays, along with familiarity with assay qualification, reproducibility standards, and data documentation practices.

Responsibilities

• Lead the design, optimization, execution, and interpretation of in vitro pharmacology assays supporting GIDDU programs.
• Design and perform experiments using primary human immune cells, including culture, stimulation, treatment, phenotyping, and functional readouts.
• Support the development, troubleshooting, qualification, and analysis of multi-parameter flow cytometry assays to evaluate mechanism of action, target engagement, and immune cell phenotypes.
• Generate reproducible, high-quality data to support program decisions and development-stage activities.
• Contribute to study design, protocol execution, data analysis, and preparation of study reports.
• Maintain accurate, complete, and inspection-ready experimental records aligned with data integrity expectations.
• Prepare technical summaries, figures, reports, and presentations that clearly communicate data, limitations, and conclusions.
• Partner with internal research, translational, biologics, regulatory, and project teams to ensure studies meet program needs.
• Identify technical challenges, troubleshoot assays, and propose practical solutions to maintain study progress.
• Contribute to project team discussions and support scientific decision-making.

Skills

In vitro pharmacology

Flow cytometry

Primary human cells

Data interpretation

Study design

Documentation

Scientific communication

Cross-functional collaboration

Troubleshooting assays

Education

Bachelor’s degree in Immunology, Cell Biology, Molecular Biology, Biotechnology, Pharmacology

Master’s degree in related field

Tools

Flow cytometer

Panel design

Staining/Acquisition/Compensation

Gating/Analysis

Job description

Takeda seeks an Associate Scientist to advance GIDDU programs through in vitro pharmacology and assay development. You will design, execute, interpret, and document studies using primary human immune cells to generate high-quality data aiding program decisions and development activities.

You will lead multi-parameter flow cytometry assay qualification and analysis, while collaborating with cross-functional teams to address challenges and ensure robust scientific progress.