Associate Scientist II, Biology

Alnylam Pharmaceuticals, Inc.; Cambridge, Northern (MA, KY); Hybrid; USD 90,000 - 120,000; Full time

Job summary

Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking an Associate Scientist II in Research to advance RNAi programs from bench to clinic, contributing to multidisciplinary efforts and enabling therapeutic development.

The role emphasizes designing and executing rodent disease model studies, in vivo siRNA evaluation, and in vitro assays like qPCR, ELISA and western blot, with strong emphasis on rigorous experimental design and teamwork.

Qualifications

• Bachelor's degree in life sciences with 1–3 years relevant experience or a Master's with 1 year relevant experience.
• Proficiency in RNA/DNA/protein analysis techniques, including RNA isolation, ELISA, western blotting and RT-qPCR
• Cell/tissue culture experience
• Basic rodent in vivo skills is a plus
• Experience setting up rodent disease models is a plus
• Ability to perform and troubleshoot assays independently or with limited supervisor direction
• Strong experimental design, data interpretation, and clear reporting
• Flexible and able to meet tight deadlines
• Proven ability to work in a team across functions

Responsibilities

• Contribute to study design and execution of RNAi program studies including rodent models
• Develop and conduct assays such as qPCR, western blot, and ELISA for in vivo and in vitro studies
• Perform in vitro and cell-based assays to characterize drug activity or mechanism of action
• Perform in vivo procedures in rodents and administer therapeutics
• Analyze and interpret data and present findings to groups
• Prepare experimental reports and develop protocols and methodologies
• Present data to internal and external groups

Skills

RNA/DNA/protein analysis

qPCR

Western blot

ELISA

Cell culture

Rodent in vivo skills

Data analysis

Experimental design

Team collaboration

Education

Bachelor's degree in life sciences (Molecular Biology, Cell Biology, Genetics)

Master's degree with 1 year experience

Job description

We are seeking a talented candidate to fill an Associate Scientist II position within Alnylam’s Research department. This position is an opportunity to potentially see one’s work progress from the bench to the clinic and positively impact patients’ lives. The successful candidate will support development of current therapeutic programs as part of a multidisciplinary team and be involved in the discovery of RNAi compounds for a variety of novel indications and support their entry into the clinic. The successful candidate will have background in biological sciences and be technically skilled in basic laboratory techniques. Responsibilities will include designing, developing, and executing studies in rodent disease models, evaluation of small interfering RNAs (siRNAs) in wild‑type animals, and conducting the associated in vitro molecular‑based assays such as transcript and protein quantitation. Collaborative curiosity, passion for science, and a desire to learn new techniques are a must.

Responsibilities

• Contribute to study design and execution of studies to characterize compounds for RNAi therapeutic programs, including rodent disease models (or other preclinical models)
• Develop and conduct assays such as qPCR, western blot, and ELISA, that support in vivo and in vitro studies
• Perform in vitro and cell‑based assays to characterize drug activity or mechanism of action
• Perform in vivo procedures in rodents, including administration of therapeutics via established methodologies
• Analyze and interpret the data
• Prepare clearly articulated experimental reports and data presentations
• Prepare and develop protocols and methodologies
• Present data to groups within and outside of Research

Qualifications

• Bachelors degree in a life sciences‑related discipline such as Molecular Biology, Cell Biology, Genetics with 1‑3 years relevant experience or a Masters degree with 1 year of relevant experience
• Proficiency in RNA/DNA/protein analysis techniques, including RNA isolation, ELISA, western blotting and RT‑qPCR
• Cell/tissue culture experience
• Basic rodent in vivo skills is a plus
• Experience setting up rodent disease models is a plus
• Ability to perform and troubleshoot assays independently or with limited direction of supervisor(s)/project leader(s)
• Demonstrate keen knowledge of experimental design, underlying scientific principles, and the ability to rigorously and independently analyze results, propose future directions and generate clear reports
• Must be flexible, open to new tasks and challenges, and able to work on tight deadlines
• Proven ability to work in a team environment and across functional areas

About Alnylam

We are the leader in RNAi therapeutics– a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize‑winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what’s possible. Our deep pipeline, late‑stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E‑Verify Employer.

The pay range below reflects the full‑time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short‑term incentive award (e.g., bonus or sales incentive) and an annual long‑term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well‑being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company‑wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well‑being reflects our belief that caring for our people fuels the impact we create together.

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