Associate Scientist I-II, Molecular Biology & Sequencing

Mosaic Biosciences; Boulder (CO); On-site; USD 57,000 - 72,000; Full time

Benefits offered by this job

Health and dental insurance

Disability and life insurance

401k with company match

Bonus opportunities

Job summary

Mosaic Biosciences seeks an Associate Scientist I-II to join the Antibody Discovery & Optimization team in Boulder, CO. The role focuses on hands-on molecular biology, sample prep for sequencing, and supporting automation-driven lab operations in a fast-paced, high-throughput setting.

The ideal candidate has hands-on PCR/qPCR and DNA purification experience and will progress toward increased independence, with exposure to sequencing data analysis and ELN/LIMS workflows.

Qualifications

• B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, or Genetics.
• Associate Scientist I: 0–2 years of relevant lab experience; Associate Scientist II: 2+ years with BS or MS.
• Hands-on experience with PCR, qPCR and DNA purification.
• Experience analyzing sequencing data (Sanger or NGS) preferred.

Responsibilities

• Perform routine molecular biology techniques including PCR, DNA purification, library preparation, cloning, and nucleic acid quantification from various sample types.
• Execute high-throughput sample preparation workflows for Sanger, Illumina, and long-read sequencing.
• Track samples throughout workflows with strong organization and documentation.
• Prepare reagents, master mixes, and consumables for daily operations.
• Analyze QC data and identify potential issues before downstream processing.
• Maintain ELNs and LIMS records with accuracy and traceability.
• Assist with inventory management and lab organization.
• Contribute to continuous improvement by identifying bottlenecks and implementing changes.
• Collaborate with sequencing, antibody discovery, and protein engineering teams to meet project timelines.
• Follow procedures and quality standards to deliver high-quality data.

Skills

Molecular biology techniques

PCR

qPCR

Data integrity

Documentation

Collaboration

Education

Bachelor's or Master's in Molecular Biology / Biochemistry / Biotechnology / Genetics

Tools

ELNs

LIMS

Geneious Biologics

Job description

Mosaic is seeking a highly motivated Associate Scientist I-II to join our Antibody Discovery & Optimization team, supporting our rapidly growing sequencing and molecular biology capabilities. This is an excellent opportunity for an early-career scientist with hands‑on molecular biology experience who enjoys working in a fast-paced, high-throughput laboratory environment.

The successful candidate will play a key role in preparing samples for sequencing, executing molecular biology workflows, and supporting automation-driven laboratory operations. Depending on experience and demonstrated capability, the individual will perform established laboratory procedures with increasing independence, contribute to troubleshooting routine technical issues, and support continuous improvement of laboratory workflows.

This position is ideal for someone who is highly organized, detail-oriented, enjoys repetitive technical work with a focus on quality, and takes pride in generating reliable, high-quality data.

Primary Responsibilities

• Perform routine molecular biology techniques including PCR, DNA purification, library preparation, cloning, and nucleic acid quantification from a variety of sample types (phage, bacteria, yeast, mammalian).
• Execute high-throughput sample preparation workflows to support Sanger, Illumina, and long-read sequencing platforms.
• Carefully track samples throughout complex workflows while maintaining exceptional organization and documentation.
• Prepare reagents, master mixes, and consumables to support daily laboratory operations.
• Analyze routine quality control data and identify potential issues before downstream processing.
• Maintain accurate laboratory records using electronic laboratory notebooks (ELNs) and laboratory information management systems (LIMS).
• Assist with inventory management, reagent preparation, and laboratory organization.
• Contribute to continuous improvement initiatives by identifying workflow bottlenecks and implementing process improvements.
• Collaborate closely with scientists across sequencing, antibody discovery, and protein engineering teams to ensure timely project execution.
• Follow established laboratory procedures, quality standards, and project timelines while maintaining a strong commitment to scientific excellence.

Qualifications

Required

• B.S. or M.S. in Molecular Biology, Biochemistry, Biotechnology, Genetics, or a related life sciences discipline.
• Candidates will be considered for the Associate Scientist I or II level based on education and relevant laboratory experience:
  • Associate Scientist I: Bachelor's degree with 0–2 years of relevant laboratory experience (including academic research, internships, or industry experience).
  • Associate Scientist II: Bachelor's degree with 2+ years of relevant industry experience or a Master's degree with relevant laboratory experience.
• Hands‑on experience with common molecular biology techniques, including PCR, qPCR and DNA purification.
• Experience with analysis of sequencing data (Sanger or NGS) and common analysis tools (ex: Geneious Biologics) preferred
• Strong organizational skills with exceptional attention to detail.
• Ability to manage multiple projects while maintaining data integrity and sample traceability.
• Excellent written and verbal communication skills.
• Comfortable working in a collaborative, fast‑paced environment.

Preferred

• Experience with automated liquid handling platforms (e.g., Opentrons, Hamilton, Tecan, Beckman, or similar).
• Familiarity with Sanger or next-generation sequencing workflows.
• Experience using ELNs, LIMS, or other laboratory data management systems.
• Exposure to antibody discovery, protein engineering, or synthetic biology workflows.

What We're Looking For

The ideal candidate is someone who enjoys laboratory work, values precision, and thrives in an environment where consistency and organization are critical. Success in this role requires someone who can execute repetitive technical workflows with a high degree of accuracy while continuously looking for opportunities to improve efficiency through organization and automation.

Candidates hired at theAssociate Scientist Ilevel will be expected to develop technical proficiency while working under established procedures and guidance. Candidates hired at theAssociate Scientist IIlevel will demonstrate greater independence, contribute to troubleshooting routine technical challenges, and help improve laboratory processes and workflow efficiency.

This individual will become an essential member of our sequencing operations, helping deliver high-quality data on tight timelines that supports cutting‑edge antibody discovery programs.

Location: This is a full-time position in Boulder, CO with in‑person work in our labs.

Base Salary Range:

• • Associate Scientist I:$57,000 - $63,000
  • Associate Scientist II:$66,000 - $72,000

As a member of our team, you will be eligible for comprehensive, competitive, flexible benefits that include health and dental insurance, disability and life insurance, 401k with company match, and bonus opportunities based on company success.