Associate Research Scientist – Formulation

Integration International Inc.; Lexington (MA); On-site; USD 50,000 - 58,000; Full time

Job summary

Integration International Inc. in Lexington, MA is seeking an Associate Research Scientist – RNAi Formulations to join a multidisciplinary team focused on non-viral delivery and formulation development for RNAi therapeutics.

This is a hands-on laboratory role emphasizing formulation preparation, biophysical characterization, analytical testing, and stability studies; collaboration spans non-viral delivery, oligonucleotide chemistry, bioanalysis, PK, and CMC teams.

Qualifications

• MS with ~3 years of relevant experience or PhD with 1–3 years in pharmaceutical sciences or related field.
• Hands-on experience with oligonucleotide or antibody/protein formulation and characterization.
• Experience with solubility, viscosity, osmolality, stability, degradation, or other developability parameters.
• Strong hands-on laboratory skills with the ability to troubleshoot formulation and characterization challenges.
• Strong experimental planning, documentation, data analysis, and problem-solving skills.
• Excellent written and verbal communication skills.

Responsibilities

• Develop and characterize RNAi and oligonucleotide formulations across projects.
• Perform formulation preparation, biophysical characterization, analytical testing, and data analysis.
• Develop and execute screening assays to evaluate formulation performance.
• Assess solubility, viscosity, osmolality, stability, degradation, and aggregation.
• Support formulation optimization using high-throughput screening and DoE approaches.
• Conduct long-term storage and stability studies for RNAi conjugates and oligonucleotide formulations.
• Troubleshoot formulation and characterization challenges, identify gaps, and propose solutions.
• Maintain accurate experimental documentation and communicate results through summaries and reports.
• Collaborate with cross-functional teams in non-viral delivery, formulation, oligonucleotide chemistry, bioanalysis, PK, CMC.
• Support project deliverables and timelines in a fast-paced, multidisciplinary research environment.

Skills

Laboratory skills

Troubleshooting

Analytical thinking

Communication skills

Oligonucleotide formulation

Education

MS with 3 years experience

PhD with 1–3 years experience

Job description

Associate Research Scientist – RNAi Formulations

Work Schedule: Monday–Friday, 8:00 AM–5:00 PM

Work Arrangement: Onsite

Duration: 1 year

Pay Rate: $39/hr on w2

We are seeking an Associate Research Scientist – RNAi Formulations to join a multidisciplinary research team focused on non-viral delivery and formulation development for RNAi and oligonucleotide therapeutics.

This is a hands-on laboratory role focused on formulation preparation, analytical and biophysical characterization, developability assessments, troubleshooting, and stability evaluation of oligonucleotide formulations for injectable therapeutics.

Key Responsibilities

• Develop and characterize preclinical RNAi and oligonucleotide formulations across portfolio and platform projects.
• Perform hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis.
• Develop and execute screening assays to evaluate formulation performance and developability.
• Assess critical formulation properties including solubility, viscosity, osmolality, stability, degradation, and aggregation.
• Support formulation optimization using high-throughput screening and Design of Experiments (DoE) approaches where applicable.
• Conduct long-term storage and stability studies for RNAi conjugates and oligonucleotide formulations.
• Troubleshoot formulation and characterization challenges, identify technical gaps, and propose practical solutions.
• Maintain accurate experimental documentation and communicate results through technical summaries, reports, and presentations.
• Collaborate with cross-functional teams in non-viral delivery, formulation, oligonucleotide chemistry, bioanalysis, PK, CMC, and related functions.
• Support project deliverables and timelines in a fast-paced, multidisciplinary research environment.

Required Qualifications

• MS with approximately 3 years of relevant experience, or PhD with 1–3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related field.
• Hands-on experience with oligonucleotide or antibody/protein formulation and characterization is strongly preferred.
• Experience with analytical methods or assessments involving solubility, viscosity, osmolality, aggregation, stability, degradation, or other developability parameters.
• Strong hands-on laboratory skills with the ability to troubleshoot formulation and characterization challenges.
• Strong experimental planning, documentation, data analysis, and problem‑solving skills.
• Excellent written and verbal communication skills and the