RNAi Formulation Scientist: Oligonucleotide Therapeutics

Integrated Resources, Inc ( IRI ); Lexington (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Integrated Resources, Inc (IRI) seeks an Associate Research Scientist Contractor, RNAi Formulations, based in Lexington, MA, within Non-Viral Delivery. The role focuses on hands-on RNAi formulation development, biophysical characterization, and support for oligonucleotide delivery activities for injectable therapeutics.

You will perform formulation preparation, analytical testing, data analysis, and collaborate with cross-functional teams to advance preclinical programs, while maintaining

Qualifications

• MS with ~3 years relevant experience OR PhD with 1-3 years
• Hands-on experience with oligonucleotide or antibodies/proteins formulation/characterization
• Experience with developability assessments (solubility, viscosity, osmolality, stability)
• Familiarity with automation and DoE-based formulation optimization
• Strong experimental planning, documentation, data analysis, problem-solving

Responsibilities

• Support development and characterization of RNAi and oligonucleotide formulations across portfolio and platform projects.
• Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments.
• Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, and stability assessments.
• Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable.
• Support long-term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations.
• Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations.
• Collaborate with internal stakeholders and external partners to support project deliverables and timelines.
• Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows.
• Thrive in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines.

Skills

RNAi formulations

Biophysical characterization

Analytical testing

DoE optimization

High-throughput screening

Scientific communication

Education

MS (3 yrs exp)

PhD (1-3 yrs)

Tools

Automation

DoE software

HTS platforms

Job description

Integrated Resources, Inc (IRI) seeks an Associate Research Scientist Contractor, RNAi Formulations, based in Lexington, MA, within Non-Viral Delivery. The role focuses on hands-on RNAi formulation development, biophysical characterization, and support for oligonucleotide delivery activities for injectable therapeutics.

You will perform formulation preparation, analytical testing, data analysis, and collaborate with cross-functional teams to advance preclinical programs, while maintaining