Associate Director, Protein Sciences & Antibody Development

EPM Scientific; San Francisco (CA); On-site; USD 180,000 - 260,000; Full time

Job summary

EPM Scientific is assisting a stealth-mode biotechnology client in San Francisco to recruit a senior scientist to lead antibody characterization, developability assessments, and early CMC efforts. The role blends hands-on protein sciences with CRO/CDMO oversight and IND-enabling development, with leadership growth potential.

The candidate will work closely with the CSO, help build the development organization, and collaborate across US/China teams, including frequent cross-functional meetings

Qualifications

• PhD in a relevant field is highly preferred; MS/BS with substantial related experience considered.
• Experience with therapeutic antibodies and protein biologics is required.
• Strong track record in antibody characterization and developability assessments.

Responsibilities

• Lead characterization and developability assessments of antibody/protein therapeutics.
• Perform expression and purification using mammalian systems (HEK293/Expi293).
• Drive analytical/biophysical studies (SEC-HPLC, CE-SDS, DLS, HIC, IEX).
• Assess QC attributes like aggregation, stability, charge variants, and solubility.
• Design formulation and forced degradation studies; support IND-CMC strategies.
• Manage CROs/CDMOs, timelines, budgets, and deliverables; cross-functional collaboration.
• Contribute to pre-IND/IND CMC documentation and tech transfer activities.

Skills

Antibody characterization

Developability assessment

Protein sciences

CRO/CDMO management

IND-enabling development

Team leadership

Education

PhD in Protein Chemistry/Biochemistry/Biophysics/Pharmaceutical Sciences or related

MS/BS with relevant experience

Tools

SEC-HPLC

CE-SDS

DLS

HIC

IEX

icIEF

DSF

nanoDSF

DSC

HEK293/Expi293 expression

Job description

EPM Scientific is assisting a stealth-mode biotechnology client in San Francisco to recruit a senior scientist to lead antibody characterization, developability assessments, and early CMC efforts. The role blends hands-on protein sciences with CRO/CDMO oversight and IND-enabling development, with leadership growth potential.

The candidate will work closely with the CSO, help build the development organization, and collaborate across US/China teams, including frequent cross-functional meetings