Associate Director, LNP Manufacturing & Scale-Up Lead

Pioneering Medicines; Cambridge (MA); Vor Ort; USD 154.000 - 204.000; Vollzeit

Zusammenfassung

Serif Biomedicines is seeking an Associate Director to join our team and lead the next generation of Programmable Medicines, focusing on lipid nanoparticle manufacturing and scale up. You will mentor scientists and work in a fast-paced, entrepreneurial environment within Flagship Pioneering's ecosystem.

Responsibilities include leading LNP scale-up, driving process development, and collaborating across disciplines to enable in vivo studies.

Qualifikationen

• Ph.D. in chemistry, chemical engineering, biochemistry, or biomedical engineering.
• Hands‑on experience scaling nucleic acid LNP formulations across upstream, downstream, and analytics.
• Familiarity with LNP analytical methods (DLS, HPLC/CAD, LC-MS, encapsulation assays).
• Experience mentoring research associates and junior scientists.

Aufgaben

• Lead LNP scale-up from small R&D formulations to NHP scale in support of a development candidate.
• Drive upstream and downstream process development, including mixing platforms (T-mix, impingement), TFF, and buffer optimization.
• Scale targeted LNPs (tLNPs), including conjugation, purification, and analytics.
• Run micro- to mid-scale formulation on microfluidics platforms (e.g., NanoAssemblr) to support platform advancement with cross-functional partners.
• Integrate QC profiling and method development (DLS, HPLC/CAD, LC-MS, encapsulation) into process development.
• Lead and mentor a team of scientists and engineers for in vivo studies.

Kenntnisse

LNP scale-up

Process development

Mentoring

Cross-functional leadership

Nucleic acid formulation

DLS/HPLC/LC-MS understanding

Ausbildung

Ph.D. in chemistry/chemical engineering/biochemistry/biomedical engineering

Tools

NanoAssemblr

TFF

HPLC/CAD/LC-MS

Jobbeschreibung

Serif Biomedicines is seeking an Associate Director to join our team and lead the next generation of Programmable Medicines, focusing on lipid nanoparticle manufacturing and scale up. You will mentor scientists and work in a fast-paced, entrepreneurial environment within Flagship Pioneering's ecosystem.

Responsibilities include leading LNP scale-up, driving process development, and collaborating across disciplines to enable in vivo studies.