Associate Director Cell Line Development

BioTalent; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

BioTalent is seeking an Associate Director of Cell Line Development in the Boston area to lead and shape our cell line development strategy for monoclonal antibodies and recombinant proteins. This is a strategic, hands-on leadership role guiding the vector design, transfection, clone screening, and cell banking efforts.

You will manage a team of scientists, drive process optimization, implement innovative technologies, and support regulatory submissions (CMC) while partnering with clients and

Qualifications

• Significant industry experience in cell line development within biopharmaceuticals.
• Deep expertise in mammalian expression systems including CHO, HEK, and NS0.
• Experience developing cell lines for monoclonal antibodies and recombinant proteins.
• Experience leading scientific teams and managing complex development programs.
• GMP, ICH guidelines, CMC activities, and statistical experimental design knowledge.
• Experience with CHO-GS systems and bispecific antibody development is advantageous.

Responsibilities

• Lead mammalian cell line development programs supporting therapeutic protein production.
• Oversee vector development, transfection, clone screening, media optimization, and cell banking.
• Manage and mentor a team of scientists and research associates.
• Drive innovation initiatives, technology implementation, and departmental growth.
• Support CMC documentation for regulatory submissions.
• Partner with clients, business development, and cross-functional technical teams.
• Contribute to strategic planning and departmental objectives.

Skills

Cell line development

Mammalian expression systems

Leadership

CMC knowledge

Statistical design

Tools

CHO-GS systems

Statistical experimental design

Job description

BioTalent are supporting a growing biopharmaceutical organization looking to add an experienced Associate Director of Cell Line Development to their leadership team.

This is a strategic and hands-on leadership role, responsible for guiding mammalian cell line development activities from vector design through stable cell line generation, clone selection, cell banking, and process optimization. You'll lead a team of scientists while helping shape the future direction of the cell line development function.

Key responsibilities:

• Lead mammalian cell line development programs supporting therapeutic protein production
• Oversee vector development, transfection, clone screening, media optimization, and cell banking activities
• Manage and mentor a team of scientists and research associates
• Drive innovation initiatives, technology implementation, and departmental growth
• Support CMC documentation for regulatory submissions
• Partner with clients, business development, and cross-functional technical teams
• Contribute to strategic planning and departmental objectives

What we're looking for:

• Significant industry experience in cell line development within biopharmaceuticals
• Deep expertise in mammalian expression systems including CHO, HEK, and NS0
• Strong background developing cell lines for monoclonal antibodies and recombinant proteins
• Experience leading scientific teams and managing complex development programs
• Knowledge of GMP, ICH guidelines, CMC activities, and statistical experimental design
• Experience with CHO-GS systems and bispecific antibody development would be highly advantageous

This is an excellent opportunity for a technical leader who enjoys building high-performing teams while driving innovation across biologics development.