Antibody Repertoire Analytics Co-Op

Boehringer Ingelheim; Ridgefield (CT); On-site; USD 33,000 - 45,000; Part time

Job summary

Boehringer Ingelheim in Ridgefield, CT is seeking a Computational Antibody Repertoire Analysis Co-Op in Biotherapeutics Research to help build a state-of-the-art NGS pipeline that prioritizes antibody hits and reduces attrition of non-binders.

You will work with BI scientists on benchmarking models, analyze single-cell and bulk immune-repertoire data, and translate computational results into experimental hypotheses while developing reproducible software and performing lineage and clonotype

Qualifications

• Must be a current undergraduate, graduate or advanced degree student in good academic standing.
• Must be enrolled at an accredited college or university for the duration of the co-op.
• GPA 3.0 on a 4.0 scale preferred.

Responsibilities

• Curate, quality-control, and analyze antibody repertoire sequencing datasets generated using platforms such as 10x Genomics and SMART-seq/BCR-seq.
• Benchmark somatic hypermutation models using predefined training and held-out test datasets.
• Evaluate model calibration, predictive performance, uncertainty, and generalization across experimental platforms.
• Apply immune-repertoire analysis tools to characterize clonotypes, lineage relationships, mutation patterns, and selection signatures.
• Contribute to an end-to-end sequence-prioritization workflow that ranks likely antigen binders and higher-affinity variants.
• Explore SHM-based features with protein language models or other machine-learning approaches.
• Develop reproducible analyses using version-controlled code, documented environments, and test datasets.
• Collaborate with computational and laboratory scientists to define validation datasets and compare rankings with binding data.
• Summarize results, limitations, and recommendations in presentations and technical documentation.

Skills

Python

R

Immunology

Statistics

Git

Workflow automation

Communication

Education

Undergraduate/Graduate student

Tools

Shazam

Dowser

Change-O

IgBLAST

MiXCR

10x Genomics

Job description

Boehringer Ingelheim in Ridgefield, CT is seeking a Computational Antibody Repertoire Analysis Co-Op in Biotherapeutics Research to help build a state-of-the-art NGS pipeline that prioritizes antibody hits and reduces attrition of non-binders.

You will work with BI scientists on benchmarking models, analyze single-cell and bulk immune-repertoire data, and translate computational results into experimental hypotheses while developing reproducible software and performing lineage and clonotype