Anitbody Research Associate II

The Fountain Group; California, South San Francisco (MO, CA); On-site; Full time

Job summary

A leading company in drug discovery is seeking a skilled candidate to contribute to the identification of macrocyclic peptides using advanced in vitro selection technologies. The role involves assay development, high-throughput screening, and data analysis, making it crucial for early drug discovery programs. Candidates should have a relevant degree and hands-on experience with display technologies.

Qualifications

• Relevant lab-based experience required.
• Hands-on experience with mRNA and phage display.

Responsibilities

• Conduct in vitro selection campaigns for macrocyclic peptides.
• Design and execute ELISA-based binding assays.
• Analyze NGS results to guide selection campaigns.

Skills

in vitro display technologies

mRNA display

phage display

data analysis

Education

B.S. in Biochemistry

M.S. in Molecular Biology

Tools

ELISA

next-generation sequencing

Job description

Details:

• Pay for this position is 41.00 to 45.52 hourly depending on experience.
• This position is a one year contract with the possibility of extension or conversion to permanent.
• Location: South San Francisco, CA

Requirements:

• B.S., M.S., or equivalent degree in Biochemistry, Molecular Biology, Chemical Biology, or a related discipline with relevant lab-based experience.
• Hands-on experience with in vitro display technologies, particularly mRNA display and/or phage display (including phage propagation and selection).

Position Summary:

• The successful candidate will contribute to the identification of Client macrocyclic peptides using in vitro selection platforms and will play a key role in assay development, high-throughput screening, and data analysis for early drug discovery programs.
• Conduct in vitro selection campaigns using mRNA and/or phage display technologies to Client active macrocyclic peptides targeting high-priority therapeutic proteins.
• Handle phage libraries, including amplification, titration, panning, and rescue procedures.
• Design and execute ELISA-based binding assays for hit validation and screening.
• Utilize laboratory automation and high-throughput screening (HTS) techniques to enable efficient assay setup, sample processing, and reagent preparation.
• Analyze next-generation sequencing (NGS) results using internal bioinformatics tools to identify early hits and guide selection campaign progression.
• Test the incorporation and expression of non-canonical amino acid monomers to enhance library diversity through genetic code expansion.
• Maintain and manage complex reagent inventories used across multiple preclinical discovery platforms.

#LI-HO1