Analytical Chemist, Physicochemical Properties

Eli Lilly and Company; Indianapolis (IN); On-site; USD 126,000 - 205,000; Full time

Benefits offered by this job

Company bonus

Comprehensive benefits package

Job summary

Lilly is seeking a highly motivated Analytical Chemist to join the Small Molecule Discovery team in Indianapolis. You will guide physicochemical property analysis and LC‑MS/SFC‑MS workflows to advance lead candidates from discovery toward clinical development.

You will collaborate with medicinal chemists and ADME/DMPK scientists, applying high-resolution MS instruments and data-processing tools to generate actionable insights and accelerate decision-making in a fast-paced environment.

Qualifications

• PhD in Analytical Chemistry, Pharmaceutical Sciences, or a closely related discipline with 5+ or Masters with 10+ years of post-education hands-on experience with LC‑MS, SFC‑MS, LC‑MS/MS, and physicochemical techniques in a small molecule pharmaceutical discovery environment.
• In-depth proven track record determining physicochemical properties and driving cross-functional impact on drug design and development.
• Experience working closely with ADME/DMPK and providing contextualized results taken from analytical data in early drug discovery.
• Well versed in analytical data/results management and extensive hand-on experience with nominal mass and high resolution LC‑MS and SFC‑MS instrumentation.

Responsibilities

• Physicochemical Property Characterization: Design and execute experiments to measure key physicochemical properties of new chemical entities and drug candidates in early discovery stages.
• LC‑MS Method Development & Application: Develop and optimize LC‑MS methods for purity, identity, and stability analysis for various pharmaceutical compounds and impurities.
• Data Analysis & Reporting: Process and interpret complex chromatographic and spectrometric data to generate actionable results for cross-functional teams.
• Documentation & Compliance: Maintain notebooks and reports per internal standards and ensure proper documentation of protocols and results.
• Innovation & Continuous Learning: Stay current with LC‑MS advancements and identify opportunities to enhance laboratory efficiency and speed up discovery.
• Cross‑Functional: Effectively partner with chemists, formulation scientists, ADME/DMPK scientists, computational scientists, and data scientists.

Skills

LC-MS

SFC-MS

LC-MS/MS

Physicochemical analysis

Data analysis

Cross-functional collaboration

Communication skills

Education

PhD in Analytical Chemistry or Pharmaceutical Sciences

Masters with 10+ years experience

Tools

MassLynx

ChemStation

Mestrelabs

KNIME

AI tools

Agilent equipment

Waters

Shimadzu

Job description

Lilly is seeking a highly motivated Analytical Chemist to join the Small Molecule Discovery team in Indianapolis. You will guide physicochemical property analysis and LC‑MS/SFC‑MS workflows to advance lead candidates from discovery toward clinical development.

You will collaborate with medicinal chemists and ADME/DMPK scientists, applying high-resolution MS instruments and data-processing tools to generate actionable insights and accelerate decision-making in a fast-paced environment.