Analytical Cell Line Engineer & Bioassay Scientist

BioLife Plasma; Lexington (MA); On-site; USD 116,000 - 182,000; Full time

Job summary

Takeda seeks a Scientist in Analytical Cell Line Engineering & Bioassay Development to design, generate, and maintain analytical cell lines for potency assays and impurity testing. You will work across Discovery, Global Biologics, and QA groups to deliver robust analytical methods and reagents.

The role involves transfection, cell banking, assay development, data interpretation, and regulatory documentation, with opportunities to influence technology transfers and process improvements.

Qualifications

• PhD in Cell Biology, Molecular Biology, Bioengineering, Biochemistry, Immunology or equivalent; or BA/BS with years of relevant experience.
• Hands-on mammalian cell culture, stable cell line engineering, flow cytometry, and molecular biology.
• Experience with transfection, transduction, clone screening, clonal isolation, cell banking, and cell line characterization.
• Experience developing and executing cell-based potency assays and functional bioassays; ELISA and qPCR methods for analytical characterization and impurity testing.

Responsibilities

• Develop, characterize, and maintain mammalian analytical cell lines for potency assays and functional characterization.
• Perform transfection, transduction, stable pool generation, clone screening, clonal isolation, and cell banking.
• Develop and run cell-based potency assays and functional bioassays; assess assay performance and resolve issues.
• Prepare technical reports, protocols, and transfer documents; support method transfers across labs and vendors.

Skills

Mammalian cell culture

Flow cytometry

Transfection

Transduction

Clonal screening

Cell banking

ELISA

qPCR

Molecular biology

Analytical development

Education

PhD in Cell Biology / Molecular Biology / Bioengineering / Biochemistry / Immunology

Master's with 3+ years industry experience

Bachelor's with 5+ years industry experience

Tools

ELISA

qPCR

Flow cytometry

Job description

Takeda seeks a Scientist in Analytical Cell Line Engineering & Bioassay Development to design, generate, and maintain analytical cell lines for potency assays and impurity testing. You will work across Discovery, Global Biologics, and QA groups to deliver robust analytical methods and reagents.

The role involves transfection, cell banking, assay development, data interpretation, and regulatory documentation, with opportunities to influence technology transfers and process improvements.