ADC Bioconjugation Scientist

Ridge Bio; San Carlos (CA); On-site; USD 110,000 - 165,000; Full time

Benefits offered by this job

Competitive compensation

Benefits package

Job summary

Ridge Biotechnologies is seeking a thoughtful scientist to advance bioconjugate therapeutics in our Bay Area team. You will work across biochemistry, protein engineering, and therapeutic development, applying NativeLink and ProTrigger technologies to progress programs with our growing partner network.

Ideal candidates bring hands-on experience in synthesis, conjugation, and bioanalytical characterization, including HT mammalian expression, antibody/ADC development, and HPLC/MS analyses.

Qualifications

• BS with 2–3 years or MS with 1–2 years in chemistry/biochemistry/related field.
• Direct hands-on experience bioconjugation methods to make biotherapeutics.
• Experience with cell-based and plate-based assays (e.g., flow cytometry, ELISA).
• Maintaining and expanding mammalian cell lines.
• Bioanalytical methods including HPLC and mass spectrometry.
• Purification of antibodies and protein conjugates (SEC, IEX, ProA, HIC, TFF).
• Hands-on synthesis and conjugation for bioconjugate therapeutics.

Responsibilities

• Develop and purify proteins and bioconjugates across scales using HT methods.
• Analyze therapeutics with assays including flow cytometry, ELISA, DSF, HIC.
• Collaborate with enzyme engineering to modify proteins for better medicines.
• Document designs and results; present to multidisciplinary teams.
• Support cell line development and therapeutic program advancement.

Skills

Bioconjugation

Cell-based assays

Mammalian cell culture

HPLC

Mass spectrometry

Protein purification

Antibody/ADC development

Synthesis & conjugation

Education

BS in Chemistry/Biochemistry/Biomedical engineering

MS in related field (optional)

Tools

HPLC

Mass spectrometry

SEC

IEX

ProA

HIC

TFF

Job description

Ridge Biotechnologies is seeking a thoughtful scientist to advance bioconjugate therapeutics in our Bay Area team. You will work across biochemistry, protein engineering, and therapeutic development, applying NativeLink and ProTrigger technologies to progress programs with our growing partner network.

Ideal candidates bring hands-on experience in synthesis, conjugation, and bioanalytical characterization, including HT mammalian expression, antibody/ADC development, and HPLC/MS analyses.