(Sr) Scientist, RNA Analytical Development

Singular: Building Brilliant Biotechs; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A biotech-focused organization in Singapore seeks a Scientist / Senior Scientist for RNA Analytical Development. The role involves developing analytical strategies, implementing advanced methods, and supporting RNA therapeutic initiatives. Candidates should possess a PhD in Analytical Chemistry and expertise in LC-MS and related analytical techniques. This full-time position requires a passion for building cutting-edge RNA analytical systems to support discovery and clinical programs.

Qualifications

• Deep experience with LC-MS, HRMS, CE-SDS, and multiscale purification techniques.
• Hands-on experience analyzing modified oligos and ligand-oligo conjugates.
• Ability to develop analytical characterization strategies for RNA raw materials.

Responsibilities

• Develop analytical characterization strategies for RNA raw materials, DS and DP.
• Implement orthogonal analytical workflows (HPLC, LC-MS, CE, UV, qPCR, DLS, TEM).
• Build scalable, phase-appropriate workflows to support discovery → IND programs.
• Develop SOPs, validation plans, and maintain rigorous documentation (LIMS/ELN).

Skills

Analytical Chemistry expertise

LC-MS experience

High-Throughput Method Development

Analytical Strategy Development

Education

PhD in Analytical Chemistry or related discipline

Tools

HPLC

LC-MS

CE

qPCR

Job description

Scientist / Senior Scientist, RNA Analytical Development

You are an analytical development scientist with deep expertise in RNA modalities, someone who thrives at the intersection of method development, platform scalability, and translational impact. You want to build analytical systems that become the backbone of an entire RNA therapeutics engine.

This organisation is building a biotech‑like translational engine designed to take novel oligo, mRNA, and conjugate programs from discovery into the clinic. Modern labs, new equipment, and a rapidly scaling team mean your analytical leadership will shape how the entire platform operates.

The Role

As Scientist / Senior Scientist, RNA Analytical Development, you will build and execute phase‑appropriate analytical strategies for raw materials (novel lipids, pDNA, ligands), drug substances (mRNA, ASOs, siRNA, gRNA), and drug products (LNPs and conjugated oligos). You will define CQAs, develop orthogonal analytical workflows, enable high‑throughput method development, and ensure the platform generates high‑quality material for pipeline programs.

Key Responsibilities

• Develop analytical characterization strategies for RNA raw materials, DS and DP
• Implement orthogonal analytical workflows (HPLC, LC‑MS, CE, UV, qPCR, DLS, TEM)
• Build scalable, phase‑appropriate workflows to support discovery → IND programs
• Develop SOPs, validation plans, and maintain rigorous documentation (LIMS/ELN)

About You

• PhD in Analytical Chemistry, Pharmaceutical Sciences, or related discipline
• Deep expertise with LC‑MS, HRMS, CE‑SDS, and multiscale purification techniques
• Hands‑on experience analysing modified oligos and ligand‑oligo conjugates

Logistics

Full‑time, Singapore‑based role within a rapidly scaling translational organisation.

If you are motivated by building cutting‑edge RNA analytical platforms from the ground up, we would love to hear from you.