Senior Scientist

Singular: Building Brilliant Biotechs; Singapore; On-site; SGD 90,000 - 120,000; Full time

Job summary

Singular: Building Brilliant Biotechs in Singapore is seeking a Senior Scientist, Bioconjugation & Targeted RNA Delivery to advance LOC-based therapies. The role is laboratory-based with strong ownership and cross-functional collaboration to push delivery performance beyond the liver.

The ideal candidate will have a PhD in a relevant field and 2–6 years of industry experience in bioconjugation or oligonucleotide therapeutics, with hands-on synthesis and analytical characte risation expertise.

Qualifications

• PhD required in a relevant chemistry/biology discipline.
• 2–6 years of industry experience in bioconjugation, targeted delivery or oligonucleotide therapeutics.
• Strong expertise in conjugation chemistry, purification and analytical characterisation.

Responsibilities

• Design and develop ligand-oligonucleotide conjugates (LOCs) for targeted RNA delivery.
• Lead hands-on synthesis, purification and analytical characterisation of novel conjugates.
• Work closely with chemists, biologists and pharmacologists to optimise in vitro and in vivo delivery performance.
• Drive project execution, manage external partners and maintain high-quality experimental data.

Skills

Bioconjugation chemistry

Targeted delivery

Oligonucleotide therapeutics

Analytical characterisation

Education

PhD in Chemistry, Chemical Biology, Medicinal Chemistry or related

Job description

Senior Scientist, Bioconjugation & Targeted RNA Delivery (Career Growth Opportunity)

You are a hands-on scientist with expertise in bioconjugation chemistry and targeted delivery technologies. You enjoy solving complex molecular design challenges in the laboratory and want to see your science translated into the next generation of therapeutics.

We are supporting a pioneering nucleic acid therapeutics programme focused on advancing innovative RNA medicines from discovery through to clinical development. Combining the pace and ambition of biotech with significant long-term investment, the organisation is building a world-class platform dedicated to unlocking the full potential of RNA-based therapies.

THE ROLE

As Senior Scientist, Bioconjugation & Targeted RNA Delivery, you will play a key role in developing ligand-oligonucleotide conjugates (LOCs) designed to enable targeted delivery beyond the liver.

This is a laboratory-based position with substantial scientific ownership. You will lead experimental programmes focused on designing, synthesising and characterising novel conjugates while working closely with multidisciplinary teams to optimise delivery, selectivity and therapeutic impact across a range of tissues. The company have aggressive growth plans over the next 5 years, this role will have significant growth opportunity within these.

KEY RESPONSIBILITIES

• Design and develop ligand-oligonucleotide conjugates (LOCs) for targeted RNA delivery.
• Lead hands-on synthesis, purification and analytical characterisation of novel conjugates.
• Work closely with chemists, biologists and pharmacologists to optimise in vitro and in vivo delivery performance.
• Drive project execution, manage external partners and maintain high-quality experimental data.

ABOUT YOU

• PhD in Chemistry, Chemical Biology, Medicinal Chemistry or a related discipline.
• 2-6 years of industry experience in bioconjugation, targeted delivery or oligonucleotide therapeutics.
• Strong expertise in conjugation chemistry, purification and analytical characterisation.

LOCATION & PACKAGE

• Singapore (Currently one of the fastest growing Biotech markets in the world)
• Competitive compensation package benchmarked against leading global biotechnology organisations
• Opportunity to contribute to cutting-edge RNA therapeutics programmes with significant scientific visibility and long-term career growth