Senior Scientist, Oligonucleotide PK/ADME Lead

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 120,000 - 180,000; Full time

Job summary

NATi at A*STAR in Singapore seeks a Scientist/Senior Scientist to lead preclinical ADME, PK, biodistribution and bioanalytical strategy for oligonucleotide therapeutics. You will drive study design, data integration, and translational modelling to inform IND-enabling decisions.

The role requires deep PK/biodistribution expertise, in vitro and in vivo assay development, and strong cross-functional collaboration in a fast-paced startup-style environment.

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Molecular Biology, or related field.
• Hands-on PK study design and analysis in oligonucleotide programs.
• Experience with biodistribution including extrahepatic tissues and bioanalytical platforms.

Responsibilities

• Design, execute, and interpret PK studies for oligonucleotides in rodent and non-rodent models.
• Characterize ADME and tissue distribution, especially extrahepatic tissues.
• Lead integration of biodistribution, PK/PD, and functional outcomes to guide candidate selection.

Skills

PK study design

Tissue biodistribution

Bioanalytical platforms

In vivo evaluation of oligonucleotides

Cross-functional leadership

Regulatory alignment

Education

PhD in Pharmacokinetics or related field

Tools

qPCR

LC-MS/MS

Hybridization assays

Job description

NATi at A*STAR in Singapore seeks a Scientist/Senior Scientist to lead preclinical ADME, PK, biodistribution and bioanalytical strategy for oligonucleotide therapeutics. You will drive study design, data integration, and translational modelling to inform IND-enabling decisions.

The role requires deep PK/biodistribution expertise, in vitro and in vivo assay development, and strong cross-functional collaboration in a fast-paced startup-style environment.