Lead Oligonucleotide PK/ADME & Bioanalytics Scientist

A*STAR Research; Singapore; On-site; SGD 120,000 - 180,000; Full time

Job summary

NATi, hosted by A*STAR in Singapore, seeks a Scientist/Senior Scientist to lead ADME, PK, biodistribution, and bioanalytical strategy for oligonucleotide therapeutics from discovery through preclinical development.

The role involves designing PK studies in rodent and non-rodent models, integrating PK/PD with tissue distribution, and driving translational strategies to support IND-enabling studies within a fast-paced, cross-functional startup environment.

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Molecular Biology, or related field.
• Minimum 4 years (Scientist) or 8 years (Senior Scientist) hands-on preclinical oligonucleotide experience.
• Experience in PK study design, tissue biodistribution including extrahepatic tissues, and bioanalytical platforms.

Responsibilities

• Design, execute, and interpret PK studies for oligonucleotides in rodent and non-rodent models.
• Lead bioanalytical strategy and ensure assays are fit-for-purpose with sensitivity and dynamic range.
• Provide scientific leadership for ADME/PK components and manage CRO collaborations.

Skills

PK study design

Tissue biodistribution

Bioanalytical platforms

In vivo evaluation

Cross-functional leadership

Education

PhD in Pharmacokinetics, Pharmaceutical Sciences, Molecular Biology, or related field

Tools

qPCR

LC-MS/MS

Hybridization assays

Job description

NATi, hosted by A*STAR in Singapore, seeks a Scientist/Senior Scientist to lead ADME, PK, biodistribution, and bioanalytical strategy for oligonucleotide therapeutics from discovery through preclinical development.

The role involves designing PK studies in rodent and non-rodent models, integrating PK/PD with tissue distribution, and driving translational strategies to support IND-enabling studies within a fast-paced, cross-functional startup environment.