Senior Oligonucleotide ADME/PK & Bioanalytics Scientist

A*STAR Research; Singapore; On-site; SGD 120,000 - 180,000; Full time

Job summary

NATi, hosted by A*STAR in Singapore, invites applications for Scientist/Senior Scientist to lead ADME/PK and bioanalytics for oligonucleotide therapeutics, accelerating programs from discovery to IND-enabling studies.

PhD in a relevant field and 4–8 years of hands-on oligonucleotide experience are required, with proven PK design, biodistribution expertise, CRO oversight, and strong cross-functional collaboration in a fast-paced startup environment.

Qualifications

• PhD in Pharmacokinetics, Pharmaceutical Sciences, Molecular Biology, or related field.
• A minimum of +4 (Scientist) or +8 (Senior Scientist) years of hands-on experience in preclinical development of oligonucleotide therapeutics
• Demonstrated expertise in PK study design and analysis, Tissue biodistribution, including extrahepatic tissues, and Bioanalytical platforms (qPCR, LC-MS/MS, hybridization assays)
• Hands-on experience leading or contributing to in vivo evaluation of targeted oligonucleotides (e.g., AOCs) with POC for extrahepatic delivery (e.g., Skeletal muscle, adipose tissue)
• Experience integrating biodistribution, PK/PD, and functional outcomes to drive candidate selection
• Experience working in metabolic disease models is highly desirable
• Demonstrated experience in project leadership or scientific ownership within cross-functional teams
• Experience establishing capabilities and working with CRO partners
• Strong analytical rigor and data-driven decision-making
• Effective communicator with the ability to influence cross-functional stakeholders

Responsibilities

• ADME, Pharmacokinetics & Translational Strategy: Design, execute, and interpret PK studies for oligonucleotides in rodent and non-rodent models.
• Bioanalytical Strategy: Develop, validate, and implement robust bioanalytical assays for oligonucleotide quantification in plasma and tissues.
• Cross-functional & Project Leadership: Provide scientific leadership for ADME/PK components and oversee external CRO studies.

Skills

PK study design

Tissue biodistribution

Bioanalytical platforms

Project leadership

Data-driven decisions

Communication

Education

PhD in Pharmacokinetics, Pharmaceutical Sciences, Molecular Biology, or related field

Tools

qPCR

LC-MS/MS

Hybridization assays

Job description

NATi, hosted by A*STAR in Singapore, invites applications for Scientist/Senior Scientist to lead ADME/PK and bioanalytics for oligonucleotide therapeutics, accelerating programs from discovery to IND-enabling studies.

PhD in a relevant field and 4–8 years of hands-on oligonucleotide experience are required, with proven PK design, biodistribution expertise, CRO oversight, and strong cross-functional collaboration in a fast-paced startup environment.