Senior Research Officer, IMCB

A*STAR - Agency for Science, Technology and Research; Singapore; On-site; SGD 60,000 - 110,000; Full time

Job summary

A*STAR - Agency for Science, Technology and Research in Singapore invites applications for a Research Fellow (RF) or Senior Research Officer to advance high-throughput proteomics and non-targeted analysis of foodborne protein hazards.

You will join a multidisciplinary team spanning Molecular Biology, Bioinformatics, and Analytical Chemistry to deliver impactful results in collaboration with government and industry partners.

Qualifications

• PhD in Biological Sciences or related field with strong publication record or 2+ years experience.
• Hands-on mass spectrometry-based proteomics experience.
• Experience in bioinformatics/biostatistics for large datasets desirable.
• Interest in collaborating with government, scientific organisations and industry partners.

Responsibilities

• Lead the technical aspects of the project and conduct research activities, including method development, data processing and result reporting, while ensuring delivery of project milestones.
• Identify problem statements, generate research hypotheses, recommend technology-based solutions and/or determine research strategies.
• Drive the proteomics component of the project across sample preparation and instrument analysis (HRMS; LC-MS/MS; DDA, DIA, PRM).
• Develop and validate new methodologies for analysis of potentially new and emerging foodborne proteins/peptide hazards in novel foods and alternative protein-based foods.
• Maintain detailed and accurate records of experimental data and results to support IP protection.
• Communicate research findings through conference presentations, scientific publications, project reports and with diverse stakeholders.
• Organise and maintain documentation of research data and project records in line with quality and audit requirements.
• Support administrative and operational works, e.g., procurement and project coordination.
• Carry out other assignments as designated by management.

Skills

Proteomics

Mass Spectrometry

Bioinformatics

Analytical Chemistry

Food Science

Research Proposal Design

Independent Working

Education

PhD in Biological Sciences

PhD in Biochemistry

PhD in Analytical Chemistry

Master's degree + 5 years experience

Job description

Job Description

One position of Research Fellow (RF) or Senior Research Officer is available for a grant project to support the high‑throughput characterization and non‑targeted analysis (NTA) of foodborne protein/peptide hazards. The candidate should have good technical experience in proteomics, mass spectrometry and food chemistry, a strong knowledge of proteomes or protein/peptide biomarkers, and an interest in working with community partners and stakeholders such as government agencies, scientific organisations and commercial companies. The candidate will play a key hands‑on role and work closely with other members and partners in a multidisciplinary team specialising in Molecular Biology, Bioinformatics, Analytical Chemistry and Food Sciences.

Scope & Duties

• Lead the technical aspects of the project and conduct research activities, including method development, data processing and result reporting, while ensuring delivery of project milestones.
• Identify problem statements, generate research hypotheses, recommend technology‑based solutions and/or determine research strategies.
• Drive the proteomics component of the project in a variety of areas, such as sample preparation, instrument analysis using high‑resolution mass spectrometry (HRMS) (e.g. LC‑MS/MS, DDA, DIA, PRM), qualitative and quantitative characterization of foodborne proteins/peptide hazards in various food matrices, hazardous biomarker discovery and validation, bioinformatic analysis, etc.
• Develop and validate new methodologies for analysis of potentially new and emerging foodborne proteins/peptide hazards in novel foods and alternative protein‑based foods, integrating multiple proteomic strategies and workflows such as bottom‑up, top‑/middle‑down and de novo peptide sequencing.
• Maintain detailed and accurate records of experimental data and results to support and protect intellectual property.
• Communicate research findings through conference presentations, scientific publications, project reports and with diverse stakeholders (e.g. scientific communities, industrial partners, policymakers).
• Organise and maintain proper documentation of research data, scientific interpretations and project records in accordance with quality and audit requirements.
• Support administrative and operational works, e.g. procurement, project coordination, etc.
• Carry out other assignments as designated by management.

Qualifications / Other Requirements

• Ph.D. in Biological Sciences, Biochemistry, Analytical Chemistry, Food Science or related disciplines, with a good publication record or at least 2 years of relevant experience in the above‑mentioned areas; alternatively, a master’s degree in the same domain with 5 years of experience.
• Proficient in the design of research proposals and execution of research projects.
• Hands‑on experience in mass spectrometry‑based proteomics research, including qualitative identification and quantitative analysis.
• Experience in bioinformatics and/or biostatistics for large‑dataset analyses is desirable.
• Expertise in research on novel foods or alternative proteins is preferred.
• Highly motivated, self‑driven to work independently in a fast‑paced environment and capable of multitasking.
• Able to co‑supervise junior staff or students.
• Good critical thinking, communication and interpersonal skills.